Cargando…

Quantitative in vivo Analyses Reveal Calcium-dependent Phosphorylation Sites and Identifies a Novel Component of the Toxoplasma Invasion Motor Complex

Apicomplexan parasites depend on the invasion of host cells for survival and proliferation. Calcium-dependent signaling pathways appear to be essential for micronemal release and gliding motility, yet the target of activated kinases remains largely unknown. We have characterized calcium-dependent ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nebl, Thomas, Prieto, Judith Helena, Kapp, Eugene, Smith, Brian J., Williams, Melanie J., Yates, John R., Cowman, Alan F., Tonkin, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182922/ https://www.ncbi.nlm.nih.gov/pubmed/21980283 http://dx.doi.org/10.1371/journal.ppat.1002222

Ejemplares similares

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii
por: Coffey, Michael J., et al.
Publicado: (2018)

TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
por: McCoy, James M., et al.
Publicado: (2012)

Correction: TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
por: McCoy, James M., et al.
Publicado: (2013)

Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii
por: Tang, Qing, et al.
Publicado: (2014)

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite
por: Leykauf, Kerstin, et al.
Publicado: (2010)

The Motor Complex of Plasmodium falciparum: PHOSPHORYLATION BY A CALCIUM-DEPENDENT PROTEIN KINASE
por: Green, Judith L., et al.
Publicado: (2008)

Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium‐dependent protein kinase 3
por: Wallbank, Bethan A., et al.
Publicado: (2018)

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
por: Hu, Ke, et al.
Publicado: (2006)

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress
por: Gaji, Rajshekhar Y., et al.
Publicado: (2015)

Calcium Uptake and Proton Transport by Acidocalcisomes of Toxoplasma gondii
por: Rohloff, Peter, et al.
Publicado: (2011)

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
por: Wilde, Mary-Louise, et al.
Publicado: (2023)

The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis
por: Treeck, Moritz, et al.
Publicado: (2014)

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility
por: Williams, Melanie J., et al.
Publicado: (2015)

Phosphorylation of Toxoplasma gondii Secreted Proteins during Acute and Chronic Stages of Infection
por: Young, Joanna C., et al.
Publicado: (2020)

Quantitative Consequences of Protein Carriers in Immunopeptidomics and Tyrosine Phosphorylation MS(2) Analyses
por: Stopfer, Lauren E., et al.
Publicado: (2021)

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii
por: Katris, Nicholas J., et al.
Publicado: (2019)

Quantitative Kinetic Analyses of Shutting Off a Two-Component System
por: Gao, Rong, et al.
Publicado: (2017)

The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation
por: Xia, Dong, et al.
Publicado: (2008)

Novel Components of the Toxoplasma Inner Membrane Complex Revealed by BioID
por: Chen, Allan L., et al.
Publicado: (2015)

An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of Toxoplasma gondii
por: Alves, Eduardo, et al.
Publicado: (2021)

Identification and Validation of Toxoplasma gondii Mitoribosomal Large Subunit Components
por: Shikha, Shikha, et al.
Publicado: (2022)

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
por: Lourido, Sebastian, et al.
Publicado: (2010)

Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine
por: Foroutan, Masoud, et al.
Publicado: (2018)

Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in Toxoplasma gondii
por: Kuchipudi, Arunakar, et al.
Publicado: (2016)

A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion
por: Coleman, Bradley I., et al.
Publicado: (2018)

Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii
por: Xie, Huanhuan, et al.
Publicado: (2023)

Toxoplasma gondii Sporozoites Invade Host Cells Using Two Novel Paralogues of RON2 and AMA1
por: Poukchanski, Anna, et al.
Publicado: (2013)

Phylogeny and virulence divergency analyses of Toxoplasma gondii isolates from China
por: Li, Min, et al.
Publicado: (2014)

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress
por: Nofal, Stephanie D., et al.
Publicado: (2022)

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell’s Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects
por: Naor, Adit, et al.
Publicado: (2018)

Genome-wide expression patterns of calcium-dependent protein kinases in Toxoplasma gondii
por: Wang, Jin-Lei, et al.
Publicado: (2015)

Characterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog
por: Kato, Kentaro, et al.
Publicado: (2016)

The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
por: CARDEW, EMILY M., et al.
Publicado: (2018)

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?
por: Baker, Tamara L., et al.
Publicado: (2020)

The Toxoplasma Acto-MyoA Motor Complex Is Important but Not Essential for Gliding Motility and Host Cell Invasion
por: Egarter, Saskia, et al.
Publicado: (2014)

Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex
por: McClatchy, Daniel B., et al.
Publicado: (2015)

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes
por: Kremer, Katrin, et al.
Publicado: (2013)

The Mechanical Components of the Dynein Motor
por: Höök, Peter
Publicado: (2010)

Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses
por: Lin, Peng-Chan, et al.
Publicado: (2016)

Protein kinase A negatively regulates Ca(2+) signalling in Toxoplasma gondii
por: Uboldi, Alessandro D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_57nqgetp3vqnj79ttes09lor2f