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Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration

Inferences of ancient sex-biased migration patterns using sex-linked genetic markers are usually difficult because of a stochastic process of allele fixation. Nevertheless, incongruent phylogenetic trees between different sex-linked markers and between sex-linked and autosomal markers are frequently...

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Autor principal: Osada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183042/
https://www.ncbi.nlm.nih.gov/pubmed/21980490
http://dx.doi.org/10.1371/journal.pone.0025549
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author Osada, Naoki
author_facet Osada, Naoki
author_sort Osada, Naoki
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description Inferences of ancient sex-biased migration patterns using sex-linked genetic markers are usually difficult because of a stochastic process of allele fixation. Nevertheless, incongruent phylogenetic trees between different sex-linked markers and between sex-linked and autosomal markers are frequently interpreted as a signature of sex-biased migration without further statistical evaluation. I investigated the types of incongruent phylogenetic trees from which past sex-biased migration events can be statistically supported under the coalescent model. In the case of mammals, detecting a sex-biased migration pattern is not guaranteed by comparing the phylogenetic pattern of mitochondrial and Y-chromosomal loci. Likewise, evidence of introgression at a mitochondrial locus, but not at autosomal loci, does not support the hypothesis of an ancient female-biased migration pattern with statistical significance. In contrast, evidence of introgression at ≥5 unlinked autosomal loci, but not at a Y-chromosomal locus, would reject the null hypothesis of a sexually equal migration rate with statistical significance. A similar argument can be made to infer a male-biased migration pattern. Furthermore, the investigation of many recombining sex-biased markers such as X-chromosomal loci in mammals has the potential to efficiently detect ancient sex-biased demographic patterns.
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spelling pubmed-31830422011-10-06 Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration Osada, Naoki PLoS One Research Article Inferences of ancient sex-biased migration patterns using sex-linked genetic markers are usually difficult because of a stochastic process of allele fixation. Nevertheless, incongruent phylogenetic trees between different sex-linked markers and between sex-linked and autosomal markers are frequently interpreted as a signature of sex-biased migration without further statistical evaluation. I investigated the types of incongruent phylogenetic trees from which past sex-biased migration events can be statistically supported under the coalescent model. In the case of mammals, detecting a sex-biased migration pattern is not guaranteed by comparing the phylogenetic pattern of mitochondrial and Y-chromosomal loci. Likewise, evidence of introgression at a mitochondrial locus, but not at autosomal loci, does not support the hypothesis of an ancient female-biased migration pattern with statistical significance. In contrast, evidence of introgression at ≥5 unlinked autosomal loci, but not at a Y-chromosomal locus, would reject the null hypothesis of a sexually equal migration rate with statistical significance. A similar argument can be made to infer a male-biased migration pattern. Furthermore, the investigation of many recombining sex-biased markers such as X-chromosomal loci in mammals has the potential to efficiently detect ancient sex-biased demographic patterns. Public Library of Science 2011-09-29 /pmc/articles/PMC3183042/ /pubmed/21980490 http://dx.doi.org/10.1371/journal.pone.0025549 Text en Naoki Osada. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Osada, Naoki
Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title_full Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title_fullStr Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title_full_unstemmed Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title_short Phylogenetic Inconsistency Caused by Ancient Sex-Biased Gene Migration
title_sort phylogenetic inconsistency caused by ancient sex-biased gene migration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183042/
https://www.ncbi.nlm.nih.gov/pubmed/21980490
http://dx.doi.org/10.1371/journal.pone.0025549
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