A Noncoding Point Mutation of Zeb1 Causes Multiple Developmental Malformations and Obesity in Twirler Mice

Heterozygous Twirler (Tw) mice develop obesity and circling behavior associated with malformations of the inner ear, whereas homozygous Tw mice have cleft palate and die shortly after birth. Zeb1 is a zinc finger protein that contributes to mesenchymal cell fate by repression of genes whose expressi...

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Detalles Bibliográficos
Autores principales: Kurima, Kiyoto, Hertzano, Ronna, Gavrilova, Oksana, Monahan, Kelly, Shpargel, Karl B., Nadaraja, Garani, Kawashima, Yoshiyuki, Lee, Kyu Yup, Ito, Taku, Higashi, Yujiro, Eisenman, David J., Strome, Scott E., Griffith, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183090/
https://www.ncbi.nlm.nih.gov/pubmed/21980308
http://dx.doi.org/10.1371/journal.pgen.1002307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183090/
https://www.ncbi.nlm.nih.gov/pubmed/21980308
http://dx.doi.org/10.1371/journal.pgen.1002307

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