Experience-dependent expression of miR132 regulates ocular dominance plasticity

MiR132 is a CREB induced microRNA involved in dendritic spine plasticity. We observed that visual experience regulates histone post-translational modifications at a CRE locus important for miR212/132 cluster transcription and miR132 expression in the visual cortex of juvenile mice. Monocular depriva...

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Detalles Bibliográficos
Autores principales: Tognini, Paola, Putignano, Elena, Coatti, Alessandro, Pizzorusso, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183093/
https://www.ncbi.nlm.nih.gov/pubmed/21892154
http://dx.doi.org/10.1038/nn.2920
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author Tognini, Paola
Putignano, Elena
Coatti, Alessandro
Pizzorusso, Tommaso
author_facet Tognini, Paola
Putignano, Elena
Coatti, Alessandro
Pizzorusso, Tommaso
author_sort Tognini, Paola
collection PubMed
description MiR132 is a CREB induced microRNA involved in dendritic spine plasticity. We observed that visual experience regulates histone post-translational modifications at a CRE locus important for miR212/132 cluster transcription and miR132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR132 expression in the cortex contralateral to the deprived eye. Counteracting miR132 reduction with infusion of chemically modified miR132 mimic oligonucleotides completely blocked ocular dominance plasticity (ODP).
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spelling pubmed-31830932012-04-01 Experience-dependent expression of miR132 regulates ocular dominance plasticity Tognini, Paola Putignano, Elena Coatti, Alessandro Pizzorusso, Tommaso Nat Neurosci Article MiR132 is a CREB induced microRNA involved in dendritic spine plasticity. We observed that visual experience regulates histone post-translational modifications at a CRE locus important for miR212/132 cluster transcription and miR132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR132 expression in the cortex contralateral to the deprived eye. Counteracting miR132 reduction with infusion of chemically modified miR132 mimic oligonucleotides completely blocked ocular dominance plasticity (ODP). 2011-09-04 /pmc/articles/PMC3183093/ /pubmed/21892154 http://dx.doi.org/10.1038/nn.2920 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Tognini, Paola
Putignano, Elena
Coatti, Alessandro
Pizzorusso, Tommaso
Experience-dependent expression of miR132 regulates ocular dominance plasticity
title Experience-dependent expression of miR132 regulates ocular dominance plasticity
title_full Experience-dependent expression of miR132 regulates ocular dominance plasticity
title_fullStr Experience-dependent expression of miR132 regulates ocular dominance plasticity
title_full_unstemmed Experience-dependent expression of miR132 regulates ocular dominance plasticity
title_short Experience-dependent expression of miR132 regulates ocular dominance plasticity
title_sort experience-dependent expression of mir132 regulates ocular dominance plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183093/
https://www.ncbi.nlm.nih.gov/pubmed/21892154
http://dx.doi.org/10.1038/nn.2920
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