miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity

Using multiple quantitative analyses, we discovered microRNAs (miRNAs) abundantly expressed in visual cortex that respond to dark-rearing (DR) and/or monocular deprivation (MD). The most significantly altered miRNA, miR-132, was rapidly upregulated after eye-opening and delayed by DR. In vivo inhibi...

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Detalles Bibliográficos
Autores principales: Mellios, Nikolaos, Sugihara, Hiroki, Castro, Jorge, Banerjee, Abhishek, Le, Chuong, Kumar, Arooshi, Crawford, Benjamin, Strathmann, Julia, Tropea, Daniela, Levine, Stuart S., Edbauer, Dieter, Sur, Mriganka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183341/
https://www.ncbi.nlm.nih.gov/pubmed/21892155
http://dx.doi.org/10.1038/nn.2909
Descripción
Sumario:Using multiple quantitative analyses, we discovered microRNAs (miRNAs) abundantly expressed in visual cortex that respond to dark-rearing (DR) and/or monocular deprivation (MD). The most significantly altered miRNA, miR-132, was rapidly upregulated after eye-opening and delayed by DR. In vivo inhibition of miR-132 prevented ocular dominance plasticity in identified neurons following MD, and affected maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.

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