miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity

Using multiple quantitative analyses, we discovered microRNAs (miRNAs) abundantly expressed in visual cortex that respond to dark-rearing (DR) and/or monocular deprivation (MD). The most significantly altered miRNA, miR-132, was rapidly upregulated after eye-opening and delayed by DR. In vivo inhibi...

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Autores principales: Mellios, Nikolaos, Sugihara, Hiroki, Castro, Jorge, Banerjee, Abhishek, Le, Chuong, Kumar, Arooshi, Crawford, Benjamin, Strathmann, Julia, Tropea, Daniela, Levine, Stuart S., Edbauer, Dieter, Sur, Mriganka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183341/
https://www.ncbi.nlm.nih.gov/pubmed/21892155
http://dx.doi.org/10.1038/nn.2909
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author Mellios, Nikolaos
Sugihara, Hiroki
Castro, Jorge
Banerjee, Abhishek
Le, Chuong
Kumar, Arooshi
Crawford, Benjamin
Strathmann, Julia
Tropea, Daniela
Levine, Stuart S.
Edbauer, Dieter
Sur, Mriganka
author_facet Mellios, Nikolaos
Sugihara, Hiroki
Castro, Jorge
Banerjee, Abhishek
Le, Chuong
Kumar, Arooshi
Crawford, Benjamin
Strathmann, Julia
Tropea, Daniela
Levine, Stuart S.
Edbauer, Dieter
Sur, Mriganka
author_sort Mellios, Nikolaos
collection PubMed
description Using multiple quantitative analyses, we discovered microRNAs (miRNAs) abundantly expressed in visual cortex that respond to dark-rearing (DR) and/or monocular deprivation (MD). The most significantly altered miRNA, miR-132, was rapidly upregulated after eye-opening and delayed by DR. In vivo inhibition of miR-132 prevented ocular dominance plasticity in identified neurons following MD, and affected maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.
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spelling pubmed-31833412012-04-01 miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong Kumar, Arooshi Crawford, Benjamin Strathmann, Julia Tropea, Daniela Levine, Stuart S. Edbauer, Dieter Sur, Mriganka Nat Neurosci Article Using multiple quantitative analyses, we discovered microRNAs (miRNAs) abundantly expressed in visual cortex that respond to dark-rearing (DR) and/or monocular deprivation (MD). The most significantly altered miRNA, miR-132, was rapidly upregulated after eye-opening and delayed by DR. In vivo inhibition of miR-132 prevented ocular dominance plasticity in identified neurons following MD, and affected maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits. 2011-09-04 /pmc/articles/PMC3183341/ /pubmed/21892155 http://dx.doi.org/10.1038/nn.2909 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mellios, Nikolaos
Sugihara, Hiroki
Castro, Jorge
Banerjee, Abhishek
Le, Chuong
Kumar, Arooshi
Crawford, Benjamin
Strathmann, Julia
Tropea, Daniela
Levine, Stuart S.
Edbauer, Dieter
Sur, Mriganka
miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title_full miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title_fullStr miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title_full_unstemmed miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title_short miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
title_sort mir-132, an experience-dependent microrna, is essential for visual cortex plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183341/
https://www.ncbi.nlm.nih.gov/pubmed/21892155
http://dx.doi.org/10.1038/nn.2909
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