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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells

INTRODUCTION: The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in immune tolerance and promotes immune escape of IDO+ tumors. A recent hypothesis suggested that IDO may contribute to the differentiation of new T regulatory cells (Tregs) from naive CD4+ T cells. In this study w...

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Detalles Bibliográficos
Autores principales:	Sun, Jingyan, Yu, Jinpu, Li, Hui, Yang, Lili, Wei, Feng, Yu, Wenwen, Liu, Juntian, Ren, Xiubao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184069/ https://www.ncbi.nlm.nih.gov/pubmed/21917155 http://dx.doi.org/10.1186/1756-9966-30-82

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