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Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B

BACKGROUND: Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir. Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investi...

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Detalles Bibliográficos
Autores principales:	Yeh, Chau-Ting, Chen, Tiffany, Hsu, Chao-Wei, Chen, Yi-Cheng, Lai, Ming-Wei, Liang, Kung-Hao, Chen, Tse-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184121/ https://www.ncbi.nlm.nih.gov/pubmed/21933446 http://dx.doi.org/10.1186/1471-2407-11-398

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