TGF-β Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence

BACKGROUND: DNA methyltransferase (DNMT) is one of the major factors mediating the methylation of cancer related genes such as TGF-β receptors (TβRs). This in turn may result in a loss of sensitivity to physiologic levels of TGF-β in aggressive prostate cancer (CaP). The specific mechanisms of DNMT&...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Chen, Lin, Helfand, Brian T., Jang, Thomas L., Sharma, Vidit, Kozlowski, James, Kuzel, Timothy Michael, Zhu, Lihua J., Yang, Ximing J., Javonovic, Borko, Guo, Yinglu, Lonning, Scott, Harper, Jay, Teicher, Beverly A., Brendler, Charles, Yu, Nengwang, Catalona, William J., Lee, Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184137/
https://www.ncbi.nlm.nih.gov/pubmed/21980391
http://dx.doi.org/10.1371/journal.pone.0025168

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