Cargando…

Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally

We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety. It was hypothesised that repeated delivery of gp140 may facilitate antigen uptake and presentation at this mucosal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewis, David J., Fraser, Carol A., Mahmoud, Abdel N., Wiggins, Rebecca C., Woodrow, Maria, Cope, Alethea, Cai, Chun, Giemza, Rafaela, Jeffs, Simon A., Manoussaka, Maria, Cole, Tom, Cranage, Martin P., Shattock, Robin J., Lacey, Charles J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184147/ https://www.ncbi.nlm.nih.gov/pubmed/21984924 http://dx.doi.org/10.1371/journal.pone.0025165

Ejemplares similares

Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
por: Curran, Rhonda M., et al.
Publicado: (2009)

Antibody responses after intravaginal immunisation with trimeric HIV-1(CN54) clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation
por: Cranage, Martin P., et al.
Publicado: (2011)

P11-11. Stable lyophilised gel vehicles for vaginal administration of recombinant C-clade HIV-1 trimeric CN54gp140
por: Donnelly, L, et al.
Publicado: (2009)

P14-06. Phase 1 safety and immunogenicity randomised controlled trial of a vaginal gp140 vaccine
por: Lewis, DJ, et al.
Publicado: (2009)

Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms
por: Donnelly, Louise, et al.
Publicado: (2011)

P11-12. A novel vaginal ring device for the sustained delivery of recombinant C-clade HIV-1 CN54gp140
por: Morrow, RJ, et al.
Publicado: (2009)

CN54gp140: product characteristics, peclinical and clinical use - recombinant glycoprotein for HIV immunization
por: Katinger, D, et al.
Publicado: (2012)

Optimising CN54gp140 plasmid delivery by comparing intramuscular and intradermal vaccination combinations with and without electroporation
por: Mann, JF, et al.
Publicado: (2012)

Antigen-specific T lymphocyte responses elicited by a DNA – MVA HIV CN54gp140 immunization regime are significantly altered by the TLR4 adjuvant GLA
por: McKay, PF, et al.
Publicado: (2012)

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
por: van Haaren, M. M., et al.
Publicado: (2021)

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
por: Klasse, P. J., et al.
Publicado: (2016)

Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery
por: Peterhoff, David, et al.
Publicado: (2021)

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
por: Sliepen, Kwinten, et al.
Publicado: (2021)

Transferrin conjugation confers mucosal molecular targeting to a model HIV-1 trimeric gp140 vaccine antigen()
por: Mann, J.F.S., et al.
Publicado: (2012)

Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein
por: Ahmed, Shubbir, et al.
Publicado: (2017)

P19-54 LB. Interrogating the membrane-proximal external region (MPER) of HIV-1 gp140
por: Jeffs, S, et al.
Publicado: (2009)

Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
por: Sattentau, Quentin J.
Publicado: (2013)

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers
por: Aldon, Yoann, et al.
Publicado: (2018)

Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations
por: Pattani, Aditya, et al.
Publicado: (2012)

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting
por: Cheng, Cheng, et al.
Publicado: (2019)

Author Correction: Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
por: Sliepen, Kwinten, et al.
Publicado: (2021)

Assessing immunogenicity barriers of the HIV-1 envelope trimer
por: Maliqi, Liridona, et al.
Publicado: (2023)

Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine
por: Cheeseman, Hannah Mary, et al.
Publicado: (2018)

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics
por: Torrents de la Peña, Alba, et al.
Publicado: (2019)

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use
por: Medina-Ramírez, Max, et al.
Publicado: (2017)

Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses
por: Hauser, Alexandra, et al.
Publicado: (2021)

Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
por: Tran, Erin E. H., et al.
Publicado: (2012)

Improving the immunogenicity of HIV-1 envelope trimer vaccines
por: Sanders, Rogier W
Publicado: (2011)

Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses
por: Bowder, Dane, et al.
Publicado: (2018)

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
por: Borst, Andrew J, et al.
Publicado: (2018)

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers
por: Gallinaro, Alessandra, et al.
Publicado: (2022)

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms
por: Brouwer, Philip J.M., et al.
Publicado: (2019)

P11-09. Mucosal vaccination with a transferrin-gp140 conjugate via the nasal but not vaginal route elicits robust systemic and vaginal IgG and IgA responses
por: Mann, JF, et al.
Publicado: (2009)

Dynamic electrophoretic fingerprinting of the HIV-1 envelope glycoprotein
por: Stieh, Daniel J, et al.
Publicado: (2013)

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro
por: Ozorowski, Gabriel, et al.
Publicado: (2018)

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
por: Mao, Youdong, et al.
Publicado: (2013)

Stabilized diverse HIV-1 envelope trimers for vaccine design
por: Wang, Qian, et al.
Publicado: (2020)

Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency
por: Manoussaka, Maria, et al.
Publicado: (2011)

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
por: Torrents de la Peña, Alba, et al.
Publicado: (2017)

Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases
por: Olia, Adam S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5qkke0cp2u1tdgjhpccb3b97gf