Cargando…
Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofun...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184413/ https://www.ncbi.nlm.nih.gov/pubmed/21977325 http://dx.doi.org/10.1155/2012/898769 |
_version_ | 1782213092883562496 |
---|---|
author | Delgado Roche, Livan Acosta Medina, Emilio Fraga Pérez, Ángela Bécquer Viart, María A. Soto López, Yosdel Falcón Cama, Viviana Vázquez López, Ana M. Martínez-Sánchez, Gregorio Fernández-Sánchez, Eduardo |
author_facet | Delgado Roche, Livan Acosta Medina, Emilio Fraga Pérez, Ángela Bécquer Viart, María A. Soto López, Yosdel Falcón Cama, Viviana Vázquez López, Ana M. Martínez-Sánchez, Gregorio Fernández-Sánchez, Eduardo |
author_sort | Delgado Roche, Livan |
collection | PubMed |
description | Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms. |
format | Online Article Text |
id | pubmed-3184413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31844132011-10-04 Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits Delgado Roche, Livan Acosta Medina, Emilio Fraga Pérez, Ángela Bécquer Viart, María A. Soto López, Yosdel Falcón Cama, Viviana Vázquez López, Ana M. Martínez-Sánchez, Gregorio Fernández-Sánchez, Eduardo Int J Vasc Med Research Article Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms. Hindawi Publishing Corporation 2012 2011-09-29 /pmc/articles/PMC3184413/ /pubmed/21977325 http://dx.doi.org/10.1155/2012/898769 Text en Copyright © 2012 Livan Delgado Roche et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Delgado Roche, Livan Acosta Medina, Emilio Fraga Pérez, Ángela Bécquer Viart, María A. Soto López, Yosdel Falcón Cama, Viviana Vázquez López, Ana M. Martínez-Sánchez, Gregorio Fernández-Sánchez, Eduardo Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title | Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title_full | Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title_fullStr | Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title_full_unstemmed | Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title_short | Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits |
title_sort | lipofundin-induced hyperlipidemia promotes oxidative stress and atherosclerotic lesions in new zealand white rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184413/ https://www.ncbi.nlm.nih.gov/pubmed/21977325 http://dx.doi.org/10.1155/2012/898769 |
work_keys_str_mv | AT delgadorochelivan lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT acostamedinaemilio lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT fragaperezangela lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT becquerviartmariaa lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT sotolopezyosdel lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT falconcamaviviana lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT vazquezlopezanam lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT martinezsanchezgregorio lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits AT fernandezsanchezeduardo lipofundininducedhyperlipidemiapromotesoxidativestressandatheroscleroticlesionsinnewzealandwhiterabbits |