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Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits

Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofun...

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Autores principales: Delgado Roche, Livan, Acosta Medina, Emilio, Fraga Pérez, Ángela, Bécquer Viart, María A., Soto López, Yosdel, Falcón Cama, Viviana, Vázquez López, Ana M., Martínez-Sánchez, Gregorio, Fernández-Sánchez, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184413/
https://www.ncbi.nlm.nih.gov/pubmed/21977325
http://dx.doi.org/10.1155/2012/898769
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author Delgado Roche, Livan
Acosta Medina, Emilio
Fraga Pérez, Ángela
Bécquer Viart, María A.
Soto López, Yosdel
Falcón Cama, Viviana
Vázquez López, Ana M.
Martínez-Sánchez, Gregorio
Fernández-Sánchez, Eduardo
author_facet Delgado Roche, Livan
Acosta Medina, Emilio
Fraga Pérez, Ángela
Bécquer Viart, María A.
Soto López, Yosdel
Falcón Cama, Viviana
Vázquez López, Ana M.
Martínez-Sánchez, Gregorio
Fernández-Sánchez, Eduardo
author_sort Delgado Roche, Livan
collection PubMed
description Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms.
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spelling pubmed-31844132011-10-04 Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits Delgado Roche, Livan Acosta Medina, Emilio Fraga Pérez, Ángela Bécquer Viart, María A. Soto López, Yosdel Falcón Cama, Viviana Vázquez López, Ana M. Martínez-Sánchez, Gregorio Fernández-Sánchez, Eduardo Int J Vasc Med Research Article Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms. Hindawi Publishing Corporation 2012 2011-09-29 /pmc/articles/PMC3184413/ /pubmed/21977325 http://dx.doi.org/10.1155/2012/898769 Text en Copyright © 2012 Livan Delgado Roche et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Delgado Roche, Livan
Acosta Medina, Emilio
Fraga Pérez, Ángela
Bécquer Viart, María A.
Soto López, Yosdel
Falcón Cama, Viviana
Vázquez López, Ana M.
Martínez-Sánchez, Gregorio
Fernández-Sánchez, Eduardo
Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title_full Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title_fullStr Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title_full_unstemmed Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title_short Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
title_sort lipofundin-induced hyperlipidemia promotes oxidative stress and atherosclerotic lesions in new zealand white rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184413/
https://www.ncbi.nlm.nih.gov/pubmed/21977325
http://dx.doi.org/10.1155/2012/898769
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