NRPS Substrate Promiscuity Diversifies the Xenematides

[Image: see text] Xenematide, a cyclic depsipeptide antibiotic produced by Xenorhabdus nematophila, had a candidate nonribosomal peptide synthetase (NRPS) with atypical features. Differential metabolite analysis between a mutant and wildtype validated that this stand-alone NRPS was required for xene...

Descripción completa

Detalles Bibliográficos
Autores principales: Crawford, Jason M., Portmann, Cyril, Kontnik, Renee, Walsh, Christopher T., Clardy, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184645/
https://www.ncbi.nlm.nih.gov/pubmed/21888371
http://dx.doi.org/10.1021/ol2020237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184645/
https://www.ncbi.nlm.nih.gov/pubmed/21888371
http://dx.doi.org/10.1021/ol2020237

Ejemplares similares