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NRPS Substrate Promiscuity Diversifies the Xenematides

[Image: see text] Xenematide, a cyclic depsipeptide antibiotic produced by Xenorhabdus nematophila, had a candidate nonribosomal peptide synthetase (NRPS) with atypical features. Differential metabolite analysis between a mutant and wildtype validated that this stand-alone NRPS was required for xene...

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Detalles Bibliográficos
Autores principales:	Crawford, Jason M., Portmann, Cyril, Kontnik, Renee, Walsh, Christopher T., Clardy, Jon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184645/ https://www.ncbi.nlm.nih.gov/pubmed/21888371 http://dx.doi.org/10.1021/ol2020237

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