Anemia and heart failure: a cause of progression or only a consequence?

Anemia is one of the most frequent co-morbidities in the patients with heart failure. Its prevalence increases from 4–7% in the subjects with asymptomatic left ventricular dysfunction to >30% in the patients with severe heart failure. Renal insufficiency, activation of inflammatory mediators, and...

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Detalles Bibliográficos
Autores principales: METRA, MARCO, NODARI, SAVINA, BORDONALI, TANIA, BUGATTI, SILVIA, FONTANELLA, BENEDETTA, LOMBARDI, CARLO, SAPORETTI, ALBERTO, VERZURA, GIULIA, DANESI, ROSSELLA, DEI CAS, LIVIO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184679/
https://www.ncbi.nlm.nih.gov/pubmed/21977269
http://dx.doi.org/10.4081/hi.2007.1
Descripción
Sumario:Anemia is one of the most frequent co-morbidities in the patients with heart failure. Its prevalence increases from 4–7% in the subjects with asymptomatic left ventricular dysfunction to >30% in the patients with severe heart failure. Renal insufficiency, activation of inflammatory mediators, and treatment with renin-angiotensin antagonists seem to be its main determinants. The results of many studies agree in showing that anemia is a powerful independent determinant of survival in patients with heart failure. However, the mechanisms of this relation are still incompletely understood. Moreover a favourable effect on prognosis of the correction of anemia has not been shown, yet, and also controlled studies assessing its effects on exercise tolerance have yielded controversial results.

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