Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat

ABSTRACT: The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the curre...

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Detalles Bibliográficos
Autores principales: Wanek, Justin, Teng, Pang-yu, Albers, John, Blair, Norman P., Shahidi, Mahnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Functional Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184865/
https://www.ncbi.nlm.nih.gov/pubmed/21991548
http://dx.doi.org/10.1364/BOE.2.
Descripción
Sumario:ABSTRACT: The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO(2)) by combined measurements of retinal blood flow and vascular oxygen tension (PO(2)) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology.

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