Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat

ABSTRACT: The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the curre...

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Autores principales: Wanek, Justin, Teng, Pang-yu, Albers, John, Blair, Norman P., Shahidi, Mahnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Functional Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184865/
https://www.ncbi.nlm.nih.gov/pubmed/21991548
http://dx.doi.org/10.1364/BOE.2.
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author Wanek, Justin
Teng, Pang-yu
Albers, John
Blair, Norman P.
Shahidi, Mahnaz
author_facet Wanek, Justin
Teng, Pang-yu
Albers, John
Blair, Norman P.
Shahidi, Mahnaz
author_sort Wanek, Justin
collection PubMed
description ABSTRACT: The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO(2)) by combined measurements of retinal blood flow and vascular oxygen tension (PO(2)) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology.
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spelling pubmed-31848652011-10-11 Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat Wanek, Justin Teng, Pang-yu Albers, John Blair, Norman P. Shahidi, Mahnaz Biomed Opt Express Functional Imaging ABSTRACT: The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO(2)) by combined measurements of retinal blood flow and vascular oxygen tension (PO(2)) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology. Optical Society of America 2011-08-09 /pmc/articles/PMC3184865/ /pubmed/21991548 http://dx.doi.org/10.1364/BOE.2. Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Functional Imaging
Wanek, Justin
Teng, Pang-yu
Albers, John
Blair, Norman P.
Shahidi, Mahnaz
Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title_full Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title_fullStr Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title_full_unstemmed Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title_short Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
title_sort inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat
topic Functional Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184865/
https://www.ncbi.nlm.nih.gov/pubmed/21991548
http://dx.doi.org/10.1364/BOE.2.
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