Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

Human small cell lung cancer (SCLC) is highly aggressive, and quickly develops resistance to therapy. SCLC cells are typically insensitive to glucocorticoids due to impaired glucocorticoid receptor (GR) expression. This is important as we have previously shown that expression of a GR transgene induc...

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Detalles Bibliográficos
Autores principales: Kay, Paul, Schlossmacher, George, Matthews, Laura, Sommer, Paula, Singh, Dave, White, Anne, Ray, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184945/
https://www.ncbi.nlm.nih.gov/pubmed/21984896
http://dx.doi.org/10.1371/journal.pone.0024839

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