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Polyamines in aging and disease

Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and poly...

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Detalles Bibliográficos
Autores principales: Minois, Nadège, Carmona-Gutierrez, Didac, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184975/
https://www.ncbi.nlm.nih.gov/pubmed/21869457
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author Minois, Nadège
Carmona-Gutierrez, Didac
Madeo, Frank
author_facet Minois, Nadège
Carmona-Gutierrez, Didac
Madeo, Frank
author_sort Minois, Nadège
collection PubMed
description Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms. Polyamines have also been involved in stress resistance. On the other hand, polyamines are increased in cancer cells and are a target for potential chemotherapeutic agents. In this review, we bring together these various results and draw a picture of the state of our knowledge on the roles of polyamines in aging, stress and diseases.
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spelling pubmed-31849752011-10-05 Polyamines in aging and disease Minois, Nadège Carmona-Gutierrez, Didac Madeo, Frank Aging (Albany NY) Review Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms. Polyamines have also been involved in stress resistance. On the other hand, polyamines are increased in cancer cells and are a target for potential chemotherapeutic agents. In this review, we bring together these various results and draw a picture of the state of our knowledge on the roles of polyamines in aging, stress and diseases. Impact Journals LLC 2011-08-21 /pmc/articles/PMC3184975/ /pubmed/21869457 Text en Copyright: © 2011 Minois et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Minois, Nadège
Carmona-Gutierrez, Didac
Madeo, Frank
Polyamines in aging and disease
title Polyamines in aging and disease
title_full Polyamines in aging and disease
title_fullStr Polyamines in aging and disease
title_full_unstemmed Polyamines in aging and disease
title_short Polyamines in aging and disease
title_sort polyamines in aging and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184975/
https://www.ncbi.nlm.nih.gov/pubmed/21869457
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