Cargando…

Phosphorylation of amyloid beta (Aβ) peptides – A trigger for formation of toxic aggregates in Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia and associated with the progressive accumulation of amyloid β-peptides (Aβ) in form of extracellular amyloid plaques in the human brain. A critical role of Aβ in the pathogenesis of AD is strongly supported by gene mutations that caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Sathish, Walter, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184981/ https://www.ncbi.nlm.nih.gov/pubmed/21869458

Ejemplares similares

Plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive Alzheimer’s disease
por: An, Seong Soo A., et al.
Publicado: (2023)

Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS
por: Liepold, Thomas, et al.
Publicado: (2023)

Oxidation destabilizes toxic amyloid beta peptide aggregation
por: Razzokov, J., et al.
Publicado: (2019)

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
por: Kumar, Sathish, et al.
Publicado: (2020)

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
por: Köppen, Janett, et al.
Publicado: (2020)

Phosphorylation modifies the molecular stability of β-amyloid deposits
por: Rezaei-Ghaleh, Nasrollah, et al.
Publicado: (2016)

Controlling Amyloid Beta Peptide Aggregation and Toxicity by Protease-Stable Ligands
por: Mallesh, Rathnam, et al.
Publicado: (2023)

Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease
por: Castillo, Willian O., et al.
Publicado: (2017)

Oxidation of Methionine-35 in Alzheimer’s amyloid-beta peptide and the aggregation of the oxidized peptide
por: Friedemann, Merlin, et al.
Publicado: (2015)

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation
por: Arbor, Sage
Publicado: (2017)

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
por: Kumar, Sathish, et al.
Publicado: (2016)

The tip of the iceberg? The underestimated potential of non-canonical beta-amyloids for Alzheimer’s disease
por: Busch, Lukas, et al.
Publicado: (2023)

Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer’s Disease
por: Sharari, Sanaa, et al.
Publicado: (2023)

Bayes analysis supports null hypothesis of anti‐amyloid beta therapy in Alzheimer's disease
por: Richard, Edo, et al.
Publicado: (2021)

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity
por: Wang, Xu, et al.
Publicado: (2013)

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity
por: Khavandi, Marzie, et al.
Publicado: (2023)

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
por: Schönherr, Caroline, et al.
Publicado: (2016)

Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease: two triggers, one disease
por: Ferreira, Sofia, et al.
Publicado: (2020)

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease
por: Boubakri, Abdelbasset, et al.
Publicado: (2020)

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR
por: Sepkhanova, I., et al.
Publicado: (2009)

Heptameric Peptide Interferes with Amyloid-β Aggregation by Structural Reorganization of the Toxic Oligomers
por: Bhattacharyya, Rajanya, et al.
Publicado: (2020)

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Small molecules to target tau amyloid aggregation
por: Manglano-Artuñedo, Zoe, et al.
Publicado: (2023)

Computational Design of New Peptide Inhibitors for Amyloid Beta (Aβ) Aggregation in Alzheimer's Disease: Application of a Novel Methodology
por: Eskici, Gözde, et al.
Publicado: (2013)

Recent advancements toward non-invasive imaging of retinal amyloid-beta for early detection of Alzheimer’s disease
por: Wang, Liang, et al.
Publicado: (2022)

Beta‐amyloid pore linked to controlled calcium influx into the cell: A new paradigm for Alzheimer's Disease
por: Pannuzzo, Martina
Publicado: (2021)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes
por: Rushworth, Jo V., et al.
Publicado: (2010)

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1–42)
por: Everett, J., et al.
Publicado: (2014)

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
por: Balakrishnan, Karthikeyan, et al.
Publicado: (2015)

Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide
por: Rezaei-Ghaleh, Nasrollah, et al.
Publicado: (2011)

Magnetoelectric dissociation of Alzheimer’s β-amyloid aggregates
por: Jang, Jinhyeong, et al.
Publicado: (2022)

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer’s disease prevention
por: Gopalakrishna, Rayudu, et al.
Publicado: (2023)

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
por: Cheng, Pin-Nan, et al.
Publicado: (2012)

Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-β story
por: Imbimbo, Bruno P., et al.
Publicado: (2022)

Misfolded amyloid-β strains and their potential roles in the clinical and pathological variability of Alzheimer’s disease
por: Kelley, Sara, et al.
Publicado: (2022)

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides
por: Huang, Yaliang, et al.
Publicado: (2021)

Key Residue for Aggregation of Amyloid-β Peptides
por: Itoh, Satoru G., et al.
Publicado: (2022)

Mechanical Dilution of Beta-amyloid Peptide and Phosphorylated Tau Protein in Alzheimer's Disease: Too Simple to be True?
por: Menéndez González, Manuel
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f60veo530jb53andm1c9qn2fjt