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Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts

Insulin-like growth factors (IGFs) are well known to play essential roles in enhancement of myogenic differentiation. In this report we showed that initial IGF-I signal activation but long-term IGF-1 signal termination are required for myogenic differentiation. L6 myoblast stably transfected with my...

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Detalles Bibliográficos
Autores principales:	Hakuno, Fumihiko, Yamauchi, Yoko, Kaneko, Gen, Yoneyama, Yosuke, Nakae, Jun, Chida, Kazuhiro, Kadowaki, Tatsuhiko, Yamanouchi, Keitaro, Nishihara, Masugi, Takahashi, Shin-Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185002/ https://www.ncbi.nlm.nih.gov/pubmed/21991327 http://dx.doi.org/10.1371/journal.pone.0025655

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