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CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome

PURPOSE: Polymorphisms of the cluster of differentiation 40 (CD40) gene have recently been identified to be associated with the risk to several immune diseases. The aim of this study was to determine the potential association of CD40 polymorphisms with Fuch uveitis syndrome (FUS). METHODS: A total o...

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Autores principales: Chen, Feilan, Hou, Shengping, Jiang, Zhengxuan, Li, Fuzhen, Chen, Yuanyuan, Kijlstra, Aize, Yang, Peizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185045/
https://www.ncbi.nlm.nih.gov/pubmed/21976957
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author Chen, Feilan
Hou, Shengping
Jiang, Zhengxuan
Li, Fuzhen
Chen, Yuanyuan
Kijlstra, Aize
Yang, Peizeng
author_facet Chen, Feilan
Hou, Shengping
Jiang, Zhengxuan
Li, Fuzhen
Chen, Yuanyuan
Kijlstra, Aize
Yang, Peizeng
author_sort Chen, Feilan
collection PubMed
description PURPOSE: Polymorphisms of the cluster of differentiation 40 (CD40) gene have recently been identified to be associated with the risk to several immune diseases. The aim of this study was to determine the potential association of CD40 polymorphisms with Fuch uveitis syndrome (FUS). METHODS: A total of 131 Han Chinese patients with FUS and 402 healthy controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype counts in patients and controls were analyzed by the χ(2) test. RESULTS: All genotypic and allelic frequencies of the tested two CD40 polymorphisms were in Hardy–Weinberg equilibrium. The genotypic and allelic frequencies of rs4810485 and rs1883832 were not different between patients with FUS and controls. No influence of sex could be found following stratification analysis according to gender. CONCLUSIONS: Our results suggest that the two investigated single-nucleotide polymorphisms (SNPs), rs4810485 and rs1883832, in CD40 are not associated with FUS in the Han Chinese population.
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spelling pubmed-31850452011-10-04 CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome Chen, Feilan Hou, Shengping Jiang, Zhengxuan Li, Fuzhen Chen, Yuanyuan Kijlstra, Aize Yang, Peizeng Mol Vis Research Article PURPOSE: Polymorphisms of the cluster of differentiation 40 (CD40) gene have recently been identified to be associated with the risk to several immune diseases. The aim of this study was to determine the potential association of CD40 polymorphisms with Fuch uveitis syndrome (FUS). METHODS: A total of 131 Han Chinese patients with FUS and 402 healthy controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype counts in patients and controls were analyzed by the χ(2) test. RESULTS: All genotypic and allelic frequencies of the tested two CD40 polymorphisms were in Hardy–Weinberg equilibrium. The genotypic and allelic frequencies of rs4810485 and rs1883832 were not different between patients with FUS and controls. No influence of sex could be found following stratification analysis according to gender. CONCLUSIONS: Our results suggest that the two investigated single-nucleotide polymorphisms (SNPs), rs4810485 and rs1883832, in CD40 are not associated with FUS in the Han Chinese population. Molecular Vision 2011-09-23 /pmc/articles/PMC3185045/ /pubmed/21976957 Text en Copyright © 2011 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Feilan
Hou, Shengping
Jiang, Zhengxuan
Li, Fuzhen
Chen, Yuanyuan
Kijlstra, Aize
Yang, Peizeng
CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title_full CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title_fullStr CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title_full_unstemmed CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title_short CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome
title_sort cd40 polymorphisms in han chinese patients with fuch uveitis syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185045/
https://www.ncbi.nlm.nih.gov/pubmed/21976957
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