Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines

The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (le...

Descripción completa

Detalles Bibliográficos
Autores principales: Boryczka, Stanisław, Mól, Wojciech, Milczarek, Magdalena, Wietrzyk, Joanna, Bębenek, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185227/
https://www.ncbi.nlm.nih.gov/pubmed/22003275
http://dx.doi.org/10.1007/s00044-010-9495-y
_version_ 1782213191262011392
author Boryczka, Stanisław
Mól, Wojciech
Milczarek, Magdalena
Wietrzyk, Joanna
Bębenek, Ewa
author_facet Boryczka, Stanisław
Mól, Wojciech
Milczarek, Magdalena
Wietrzyk, Joanna
Bębenek, Ewa
author_sort Boryczka, Stanisław
collection PubMed
description The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID(50) values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds.
format Online
Article
Text
id pubmed-3185227
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-31852272011-10-12 Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines Boryczka, Stanisław Mól, Wojciech Milczarek, Magdalena Wietrzyk, Joanna Bębenek, Ewa Med Chem Res Original Research The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID(50) values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds. Springer-Verlag 2010-11-17 2011 /pmc/articles/PMC3185227/ /pubmed/22003275 http://dx.doi.org/10.1007/s00044-010-9495-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Research
Boryczka, Stanisław
Mól, Wojciech
Milczarek, Magdalena
Wietrzyk, Joanna
Bębenek, Ewa
Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title_full Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title_fullStr Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title_full_unstemmed Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title_short Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
title_sort synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185227/
https://www.ncbi.nlm.nih.gov/pubmed/22003275
http://dx.doi.org/10.1007/s00044-010-9495-y
work_keys_str_mv AT boryczkastanisław synthesisandinvitroantiproliferativeactivityofnovel4chloroand4acyloxy2butynylthioquinolines
AT molwojciech synthesisandinvitroantiproliferativeactivityofnovel4chloroand4acyloxy2butynylthioquinolines
AT milczarekmagdalena synthesisandinvitroantiproliferativeactivityofnovel4chloroand4acyloxy2butynylthioquinolines
AT wietrzykjoanna synthesisandinvitroantiproliferativeactivityofnovel4chloroand4acyloxy2butynylthioquinolines
AT bebenekewa synthesisandinvitroantiproliferativeactivityofnovel4chloroand4acyloxy2butynylthioquinolines

Ejemplares similares