Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma

Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by...

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Autores principales: Stanczak, Aleksandra, Stec, Rafal, Bodnar, Lubomir, Olszewski, Wojciech, Cichowicz, Marzena, Kozlowski, Wojciech, Szczylik, Cezary, Pietrucha, Tadeusz, Wieczorek, Maciej, Lamparska-Przybysz, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185231/
https://www.ncbi.nlm.nih.gov/pubmed/21678109
http://dx.doi.org/10.1007/s12253-011-9409-4
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author Stanczak, Aleksandra
Stec, Rafal
Bodnar, Lubomir
Olszewski, Wojciech
Cichowicz, Marzena
Kozlowski, Wojciech
Szczylik, Cezary
Pietrucha, Tadeusz
Wieczorek, Maciej
Lamparska-Przybysz, Monika
author_facet Stanczak, Aleksandra
Stec, Rafal
Bodnar, Lubomir
Olszewski, Wojciech
Cichowicz, Marzena
Kozlowski, Wojciech
Szczylik, Cezary
Pietrucha, Tadeusz
Wieczorek, Maciej
Lamparska-Przybysz, Monika
author_sort Stanczak, Aleksandra
collection PubMed
description Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, β-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear β-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/β-catenin pathway plays an important role in advanced colorectal carcinoma.
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spelling pubmed-31852312011-10-12 Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma Stanczak, Aleksandra Stec, Rafal Bodnar, Lubomir Olszewski, Wojciech Cichowicz, Marzena Kozlowski, Wojciech Szczylik, Cezary Pietrucha, Tadeusz Wieczorek, Maciej Lamparska-Przybysz, Monika Pathol Oncol Res Research Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, β-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear β-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/β-catenin pathway plays an important role in advanced colorectal carcinoma. Springer Netherlands 2011-06-16 2011 /pmc/articles/PMC3185231/ /pubmed/21678109 http://dx.doi.org/10.1007/s12253-011-9409-4 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research
Stanczak, Aleksandra
Stec, Rafal
Bodnar, Lubomir
Olszewski, Wojciech
Cichowicz, Marzena
Kozlowski, Wojciech
Szczylik, Cezary
Pietrucha, Tadeusz
Wieczorek, Maciej
Lamparska-Przybysz, Monika
Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title_full Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title_fullStr Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title_full_unstemmed Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title_short Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
title_sort prognostic significance of wnt-1, β-catenin and e-cadherin expression in advanced colorectal carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185231/
https://www.ncbi.nlm.nih.gov/pubmed/21678109
http://dx.doi.org/10.1007/s12253-011-9409-4
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