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Acoustic Analysis of PD Speech
According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185254/ https://www.ncbi.nlm.nih.gov/pubmed/21977333 http://dx.doi.org/10.4061/2011/435232 |
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author | Chenausky, Karen MacAuslan, Joel Goldhor, Richard |
author_facet | Chenausky, Karen MacAuslan, Joel Goldhor, Richard |
author_sort | Chenausky, Karen |
collection | PubMed |
description | According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substantially relieves motor symptoms in advanced-stage patients for whom medication produces disabling dyskinesias. This study investigated speech changes as a result of DBS settings chosen to maximize motor performance. The speech of 10 PD patients and 12 normal controls was analyzed for syllable rate and variability, syllable length patterning, vowel fraction, voice-onset time variability, and spirantization. These were normalized by the controls' standard deviation to represent distance from normal and combined into a composite measure. Results show that DBS settings relieving motor symptoms can improve speech, making it up to three standard deviations closer to normal. However, the clinically motivated settings evaluated here show greater capacity to impair, rather than improve, speech. A feedback device developed from these findings could be useful to clinicians adjusting DBS parameters, as a means for ensuring they do not unwittingly choose DBS settings which impair patients' communication. |
format | Online Article Text |
id | pubmed-3185254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31852542011-10-04 Acoustic Analysis of PD Speech Chenausky, Karen MacAuslan, Joel Goldhor, Richard Parkinsons Dis Research Article According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substantially relieves motor symptoms in advanced-stage patients for whom medication produces disabling dyskinesias. This study investigated speech changes as a result of DBS settings chosen to maximize motor performance. The speech of 10 PD patients and 12 normal controls was analyzed for syllable rate and variability, syllable length patterning, vowel fraction, voice-onset time variability, and spirantization. These were normalized by the controls' standard deviation to represent distance from normal and combined into a composite measure. Results show that DBS settings relieving motor symptoms can improve speech, making it up to three standard deviations closer to normal. However, the clinically motivated settings evaluated here show greater capacity to impair, rather than improve, speech. A feedback device developed from these findings could be useful to clinicians adjusting DBS parameters, as a means for ensuring they do not unwittingly choose DBS settings which impair patients' communication. SAGE-Hindawi Access to Research 2011 2011-10-03 /pmc/articles/PMC3185254/ /pubmed/21977333 http://dx.doi.org/10.4061/2011/435232 Text en Copyright © 2011 Karen Chenausky et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chenausky, Karen MacAuslan, Joel Goldhor, Richard Acoustic Analysis of PD Speech |
title | Acoustic Analysis of PD Speech |
title_full | Acoustic Analysis of PD Speech |
title_fullStr | Acoustic Analysis of PD Speech |
title_full_unstemmed | Acoustic Analysis of PD Speech |
title_short | Acoustic Analysis of PD Speech |
title_sort | acoustic analysis of pd speech |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185254/ https://www.ncbi.nlm.nih.gov/pubmed/21977333 http://dx.doi.org/10.4061/2011/435232 |
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