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Acoustic Analysis of PD Speech

According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substa...

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Autores principales: Chenausky, Karen, MacAuslan, Joel, Goldhor, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185254/
https://www.ncbi.nlm.nih.gov/pubmed/21977333
http://dx.doi.org/10.4061/2011/435232
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author Chenausky, Karen
MacAuslan, Joel
Goldhor, Richard
author_facet Chenausky, Karen
MacAuslan, Joel
Goldhor, Richard
author_sort Chenausky, Karen
collection PubMed
description According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substantially relieves motor symptoms in advanced-stage patients for whom medication produces disabling dyskinesias. This study investigated speech changes as a result of DBS settings chosen to maximize motor performance. The speech of 10 PD patients and 12 normal controls was analyzed for syllable rate and variability, syllable length patterning, vowel fraction, voice-onset time variability, and spirantization. These were normalized by the controls' standard deviation to represent distance from normal and combined into a composite measure. Results show that DBS settings relieving motor symptoms can improve speech, making it up to three standard deviations closer to normal. However, the clinically motivated settings evaluated here show greater capacity to impair, rather than improve, speech. A feedback device developed from these findings could be useful to clinicians adjusting DBS parameters, as a means for ensuring they do not unwittingly choose DBS settings which impair patients' communication.
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spelling pubmed-31852542011-10-04 Acoustic Analysis of PD Speech Chenausky, Karen MacAuslan, Joel Goldhor, Richard Parkinsons Dis Research Article According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD), with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS) substantially relieves motor symptoms in advanced-stage patients for whom medication produces disabling dyskinesias. This study investigated speech changes as a result of DBS settings chosen to maximize motor performance. The speech of 10 PD patients and 12 normal controls was analyzed for syllable rate and variability, syllable length patterning, vowel fraction, voice-onset time variability, and spirantization. These were normalized by the controls' standard deviation to represent distance from normal and combined into a composite measure. Results show that DBS settings relieving motor symptoms can improve speech, making it up to three standard deviations closer to normal. However, the clinically motivated settings evaluated here show greater capacity to impair, rather than improve, speech. A feedback device developed from these findings could be useful to clinicians adjusting DBS parameters, as a means for ensuring they do not unwittingly choose DBS settings which impair patients' communication. SAGE-Hindawi Access to Research 2011 2011-10-03 /pmc/articles/PMC3185254/ /pubmed/21977333 http://dx.doi.org/10.4061/2011/435232 Text en Copyright © 2011 Karen Chenausky et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chenausky, Karen
MacAuslan, Joel
Goldhor, Richard
Acoustic Analysis of PD Speech
title Acoustic Analysis of PD Speech
title_full Acoustic Analysis of PD Speech
title_fullStr Acoustic Analysis of PD Speech
title_full_unstemmed Acoustic Analysis of PD Speech
title_short Acoustic Analysis of PD Speech
title_sort acoustic analysis of pd speech
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185254/
https://www.ncbi.nlm.nih.gov/pubmed/21977333
http://dx.doi.org/10.4061/2011/435232
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