Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

Messenger RNA localization involves the assembly of ribonucleoprotein particles (RNPs) and their subsequent transport along the cytoskeleton to their final destination. Here, we provide new evidence that microtubule-associated protein 2 (MAP2), calcium/calmodulin-dependent protein kinase II (CaMKIIα...

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Detalles Bibliográficos
Autores principales: Mikl, Martin, Vendra, Georgia, Kiebler, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185336/
https://www.ncbi.nlm.nih.gov/pubmed/21869818
http://dx.doi.org/10.1038/embor.2011.149
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author Mikl, Martin
Vendra, Georgia
Kiebler, Michael A
author_facet Mikl, Martin
Vendra, Georgia
Kiebler, Michael A
author_sort Mikl, Martin
collection PubMed
description Messenger RNA localization involves the assembly of ribonucleoprotein particles (RNPs) and their subsequent transport along the cytoskeleton to their final destination. Here, we provide new evidence that microtubule-associated protein 2 (MAP2), calcium/calmodulin-dependent protein kinase II (CaMKIIα) and β-actin RNAs localize to dendrites in distinct RNPs, which contain—unexpectedly—very few RNA molecules. The number of MAP2 molecules per particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is tightly controlled. Our data suggest that the independent localization of individual RNAs in low copy numbers could contribute to tighter temporal and spatial control of expression in neurons and synapse-specific plasticity.
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spelling pubmed-31853362011-11-04 Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers Mikl, Martin Vendra, Georgia Kiebler, Michael A EMBO Rep Scientific Reports Messenger RNA localization involves the assembly of ribonucleoprotein particles (RNPs) and their subsequent transport along the cytoskeleton to their final destination. Here, we provide new evidence that microtubule-associated protein 2 (MAP2), calcium/calmodulin-dependent protein kinase II (CaMKIIα) and β-actin RNAs localize to dendrites in distinct RNPs, which contain—unexpectedly—very few RNA molecules. The number of MAP2 molecules per particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is tightly controlled. Our data suggest that the independent localization of individual RNAs in low copy numbers could contribute to tighter temporal and spatial control of expression in neurons and synapse-specific plasticity. European Molecular Biology Organization 2011-10 2011-08-26 /pmc/articles/PMC3185336/ /pubmed/21869818 http://dx.doi.org/10.1038/embor.2011.149 Text en Copyright © 2011, European Molecular Biology Organization https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Scientific Reports
Mikl, Martin
Vendra, Georgia
Kiebler, Michael A
Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title_full Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title_fullStr Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title_full_unstemmed Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title_short Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
title_sort independent localization of map2, camkiiα and β-actin rnas in low copy numbers
topic Scientific Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185336/
https://www.ncbi.nlm.nih.gov/pubmed/21869818
http://dx.doi.org/10.1038/embor.2011.149
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