Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transi...

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Detalles Bibliográficos
Autores principales: Wu, Bin, Davey, Gabriela E., Nazarov, Alexey A., Dyson, Paul J., Davey, Curt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185412/
https://www.ncbi.nlm.nih.gov/pubmed/21724603
http://dx.doi.org/10.1093/nar/gkr491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185412/
https://www.ncbi.nlm.nih.gov/pubmed/21724603
http://dx.doi.org/10.1093/nar/gkr491

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