Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS

The DNA mismatch repair protein MutS recognizes mispaired bases in DNA and initiates repair in an ATP-dependent manner. Understanding of the allosteric coupling between DNA mismatch recognition and two asymmetric nucleotide binding sites at opposing sides of the MutS dimer requires identification of...

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Detalles Bibliográficos
Autores principales: Monti, Maria Chiara, Cohen, Serge X., Fish, Alexander, Winterwerp, Herrie H. K., Barendregt, Arjan, Friedhoff, Peter, Perrakis, Anastassis, Heck, Albert J. R., Sixma, Titia K., van den Heuvel, Robert H. H., Lebbink, Joyce H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185415/
https://www.ncbi.nlm.nih.gov/pubmed/21737427
http://dx.doi.org/10.1093/nar/gkr498

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