Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations

The difference in melting temperature of a double-stranded (ds) DNA molecule in the absence and presence of bound ligands can provide experimental information about the stabilization brought about by ligand binding. By simulating the dynamic behaviour of a duplex of sequence 5′-d(TAATAACGGATTATT)·5′...

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Detalles Bibliográficos
Autores principales: Bueren-Calabuig, Juan A., Giraudon, Christophe, Galmarini, Carlos M., Egly, Jean Marc, Gago, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185422/
https://www.ncbi.nlm.nih.gov/pubmed/21727089
http://dx.doi.org/10.1093/nar/gkr512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185422/
https://www.ncbi.nlm.nih.gov/pubmed/21727089
http://dx.doi.org/10.1093/nar/gkr512

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