Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress

The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The obj...

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Detalles Bibliográficos
Autores principales: Clément, Sophie, Pascarella, Stéphanie, Negro, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185489/
https://www.ncbi.nlm.nih.gov/pubmed/21994542
http://dx.doi.org/10.3390/v1020126
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author Clément, Sophie
Pascarella, Stéphanie
Negro, Francesco
author_facet Clément, Sophie
Pascarella, Stéphanie
Negro, Francesco
author_sort Clément, Sophie
collection PubMed
description The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The objective of this review is to discuss three of these cofactors: steatosis, insulin resistance and oxidative stress. Although all may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. This review summarizes the current understanding and potential molecular pathways by which HCV contributes to their development.
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spelling pubmed-31854892011-10-12 Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress Clément, Sophie Pascarella, Stéphanie Negro, Francesco Viruses Review The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The objective of this review is to discuss three of these cofactors: steatosis, insulin resistance and oxidative stress. Although all may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. This review summarizes the current understanding and potential molecular pathways by which HCV contributes to their development. Molecular Diversity Preservation International (MDPI) 2009-08-11 /pmc/articles/PMC3185489/ /pubmed/21994542 http://dx.doi.org/10.3390/v1020126 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Clément, Sophie
Pascarella, Stéphanie
Negro, Francesco
Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title_full Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title_fullStr Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title_full_unstemmed Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title_short Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative Stress
title_sort hepatitis c virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185489/
https://www.ncbi.nlm.nih.gov/pubmed/21994542
http://dx.doi.org/10.3390/v1020126
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