HBV Life Cycle: Entry and Morphogenesis

Hepatitis B virus (HBV) is a major cause of liver disease. HBV primarily infects hepatocytes by a still poorly understood mechanism. After an endocytotic process, the nucleocapsids are released into the cytoplasm and the relaxed circular rcDNA genome is transported towards the nucleus where it is co...

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Detalles Bibliográficos
Autores principales: Schädler, Stephanie, Hildt, Eberhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185491/
https://www.ncbi.nlm.nih.gov/pubmed/21994545
http://dx.doi.org/10.3390/v1020185
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author Schädler, Stephanie
Hildt, Eberhard
author_facet Schädler, Stephanie
Hildt, Eberhard
author_sort Schädler, Stephanie
collection PubMed
description Hepatitis B virus (HBV) is a major cause of liver disease. HBV primarily infects hepatocytes by a still poorly understood mechanism. After an endocytotic process, the nucleocapsids are released into the cytoplasm and the relaxed circular rcDNA genome is transported towards the nucleus where it is converted into covalently closed circular cccDNA. Replication of the viral genome occurs via an RNA pregenome (pgRNA) that binds to HBV polymerase (P). P initiates pgRNA encapsidation and reverse transcription inside the capsid. Matured, rcDNA containing nucleocapsids can re-deliver the RC-DNA to the nucleus, or be secreted via interaction with the envelope proteins as progeny virions.
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spelling pubmed-31854912011-10-12 HBV Life Cycle: Entry and Morphogenesis Schädler, Stephanie Hildt, Eberhard Viruses Review Hepatitis B virus (HBV) is a major cause of liver disease. HBV primarily infects hepatocytes by a still poorly understood mechanism. After an endocytotic process, the nucleocapsids are released into the cytoplasm and the relaxed circular rcDNA genome is transported towards the nucleus where it is converted into covalently closed circular cccDNA. Replication of the viral genome occurs via an RNA pregenome (pgRNA) that binds to HBV polymerase (P). P initiates pgRNA encapsidation and reverse transcription inside the capsid. Matured, rcDNA containing nucleocapsids can re-deliver the RC-DNA to the nucleus, or be secreted via interaction with the envelope proteins as progeny virions. Molecular Diversity Preservation International (MDPI) 2009-09-01 /pmc/articles/PMC3185491/ /pubmed/21994545 http://dx.doi.org/10.3390/v1020185 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Schädler, Stephanie
Hildt, Eberhard
HBV Life Cycle: Entry and Morphogenesis
title HBV Life Cycle: Entry and Morphogenesis
title_full HBV Life Cycle: Entry and Morphogenesis
title_fullStr HBV Life Cycle: Entry and Morphogenesis
title_full_unstemmed HBV Life Cycle: Entry and Morphogenesis
title_short HBV Life Cycle: Entry and Morphogenesis
title_sort hbv life cycle: entry and morphogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185491/
https://www.ncbi.nlm.nih.gov/pubmed/21994545
http://dx.doi.org/10.3390/v1020185
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