Adaptive Immunity to Hepatitis C Virus

The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This revie...

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Detalles Bibliográficos
Autores principales: Zeisel, Mirjam B., Fafi-Kremer, Samira, Robinet, Eric, Habersetzer, François, Baumert, Thomas F., Stoll-Keller, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185498/
https://www.ncbi.nlm.nih.gov/pubmed/21994550
http://dx.doi.org/10.3390/v1020276
Descripción
Sumario:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection.

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