Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus

Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this...

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Autores principales: Melchjorsen, Jesper, Matikainen, Sampsa, Paludan, Søren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185509/
https://www.ncbi.nlm.nih.gov/pubmed/21994567
http://dx.doi.org/10.3390/v1030737
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author Melchjorsen, Jesper
Matikainen, Sampsa
Paludan, Søren R.
author_facet Melchjorsen, Jesper
Matikainen, Sampsa
Paludan, Søren R.
author_sort Melchjorsen, Jesper
collection PubMed
description Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV.
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spelling pubmed-31855092011-10-12 Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus Melchjorsen, Jesper Matikainen, Sampsa Paludan, Søren R. Viruses Review Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV. Molecular Diversity Preservation International (MDPI) 2009-11-05 /pmc/articles/PMC3185509/ /pubmed/21994567 http://dx.doi.org/10.3390/v1030737 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Melchjorsen, Jesper
Matikainen, Sampsa
Paludan, Søren R.
Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title_full Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title_fullStr Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title_full_unstemmed Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title_short Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
title_sort activation and evasion of innate antiviral immunity by herpes simplex virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185509/
https://www.ncbi.nlm.nih.gov/pubmed/21994567
http://dx.doi.org/10.3390/v1030737
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