Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections

One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity agai...

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Detalles Bibliográficos
Autor principal: Jenssen, Håvard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185547/
https://www.ncbi.nlm.nih.gov/pubmed/21994576
http://dx.doi.org/10.3390/v1030939
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author Jenssen, Håvard
author_facet Jenssen, Håvard
author_sort Jenssen, Håvard
collection PubMed
description One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity against HSV. New evidence has also indicated that these host defence peptides are able to selectively stimulate the innate immune system to fight of infections. This review will focus on the anti-HSV activity of such peptides (both natural and synthetic), describe their mode of action and their clinical potential.
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spelling pubmed-31855472011-10-12 Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections Jenssen, Håvard Viruses Review One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity against HSV. New evidence has also indicated that these host defence peptides are able to selectively stimulate the innate immune system to fight of infections. This review will focus on the anti-HSV activity of such peptides (both natural and synthetic), describe their mode of action and their clinical potential. Molecular Diversity Preservation International (MDPI) 2009-11-18 /pmc/articles/PMC3185547/ /pubmed/21994576 http://dx.doi.org/10.3390/v1030939 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jenssen, Håvard
Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title_full Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title_fullStr Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title_full_unstemmed Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title_short Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
title_sort therapeutic approaches using host defence peptides to tackle herpes virus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185547/
https://www.ncbi.nlm.nih.gov/pubmed/21994576
http://dx.doi.org/10.3390/v1030939
work_keys_str_mv AT jenssenhavard therapeuticapproachesusinghostdefencepeptidestotackleherpesvirusinfections

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