Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery

Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Seto, Jason, Walsh, Michael P., Mahadevan, Padmanabhan, Zhang, Qiwei, Seto, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185558/
https://www.ncbi.nlm.nih.gov/pubmed/21994597
http://dx.doi.org/10.3390/v2010001
_version_ 1782213232544448512
author Seto, Jason
Walsh, Michael P.
Mahadevan, Padmanabhan
Zhang, Qiwei
Seto, Donald
author_facet Seto, Jason
Walsh, Michael P.
Mahadevan, Padmanabhan
Zhang, Qiwei
Seto, Donald
author_sort Seto, Jason
collection PubMed
description Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide effective prophylactics. The same data and approaches can be applied to vector development for gene delivery in gene therapy and vaccine delivery protocols. Examination of several field strain genomes and their analyses provide examples of data that are available using these approaches. An example of the development of HAdV-B3 both as a vaccine and also as a vector is presented.
format Online
Article
Text
id pubmed-3185558
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-31855582011-10-12 Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery Seto, Jason Walsh, Michael P. Mahadevan, Padmanabhan Zhang, Qiwei Seto, Donald Viruses Review Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide effective prophylactics. The same data and approaches can be applied to vector development for gene delivery in gene therapy and vaccine delivery protocols. Examination of several field strain genomes and their analyses provide examples of data that are available using these approaches. An example of the development of HAdV-B3 both as a vaccine and also as a vector is presented. Molecular Diversity Preservation International (MDPI) 2010-01-06 /pmc/articles/PMC3185558/ /pubmed/21994597 http://dx.doi.org/10.3390/v2010001 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Seto, Jason
Walsh, Michael P.
Mahadevan, Padmanabhan
Zhang, Qiwei
Seto, Donald
Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title_full Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title_fullStr Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title_full_unstemmed Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title_short Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery
title_sort applying genomic and bioinformatic resources to human adenovirus genomes for use in vaccine development and for applications in vector development for gene delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185558/
https://www.ncbi.nlm.nih.gov/pubmed/21994597
http://dx.doi.org/10.3390/v2010001
work_keys_str_mv AT setojason applyinggenomicandbioinformaticresourcestohumanadenovirusgenomesforuseinvaccinedevelopmentandforapplicationsinvectordevelopmentforgenedelivery
AT walshmichaelp applyinggenomicandbioinformaticresourcestohumanadenovirusgenomesforuseinvaccinedevelopmentandforapplicationsinvectordevelopmentforgenedelivery
AT mahadevanpadmanabhan applyinggenomicandbioinformaticresourcestohumanadenovirusgenomesforuseinvaccinedevelopmentandforapplicationsinvectordevelopmentforgenedelivery
AT zhangqiwei applyinggenomicandbioinformaticresourcestohumanadenovirusgenomesforuseinvaccinedevelopmentandforapplicationsinvectordevelopmentforgenedelivery
AT setodonald applyinggenomicandbioinformaticresourcestohumanadenovirusgenomesforuseinvaccinedevelopmentandforapplicationsinvectordevelopmentforgenedelivery

Ejemplares similares