Development of Viral Vectors for Use in Cardiovascular Gene Therapy

Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing benefits in the clinical setting. In this rev...

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Detalles Bibliográficos
Autores principales: Williams, Paul D., Ranjzad, Parisa, Kakar, Salik J., Kingston, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185614/
https://www.ncbi.nlm.nih.gov/pubmed/21994642
http://dx.doi.org/10.3390/v2020334
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author Williams, Paul D.
Ranjzad, Parisa
Kakar, Salik J.
Kingston, Paul A.
author_facet Williams, Paul D.
Ranjzad, Parisa
Kakar, Salik J.
Kingston, Paul A.
author_sort Williams, Paul D.
collection PubMed
description Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing benefits in the clinical setting. In this review we discuss the various targets which may be suitable for cardiovascular gene therapy and the viral vectors which have to date shown the most potential for clinical use. We conclude with a summary of the current state of clinical cardiovascular gene therapy and the key trials which are ongoing.
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spelling pubmed-31856142011-10-12 Development of Viral Vectors for Use in Cardiovascular Gene Therapy Williams, Paul D. Ranjzad, Parisa Kakar, Salik J. Kingston, Paul A. Viruses Review Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing benefits in the clinical setting. In this review we discuss the various targets which may be suitable for cardiovascular gene therapy and the viral vectors which have to date shown the most potential for clinical use. We conclude with a summary of the current state of clinical cardiovascular gene therapy and the key trials which are ongoing. Molecular Diversity Preservation International (MDPI) 2010-01-27 /pmc/articles/PMC3185614/ /pubmed/21994642 http://dx.doi.org/10.3390/v2020334 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Williams, Paul D.
Ranjzad, Parisa
Kakar, Salik J.
Kingston, Paul A.
Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title_full Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title_fullStr Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title_full_unstemmed Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title_short Development of Viral Vectors for Use in Cardiovascular Gene Therapy
title_sort development of viral vectors for use in cardiovascular gene therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185614/
https://www.ncbi.nlm.nih.gov/pubmed/21994642
http://dx.doi.org/10.3390/v2020334
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AT ranjzadparisa developmentofviralvectorsforuseincardiovasculargenetherapy
AT kakarsalikj developmentofviralvectorsforuseincardiovasculargenetherapy
AT kingstonpaula developmentofviralvectorsforuseincardiovasculargenetherapy

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