The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in rel...

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Autores principales: Friis, Anna M. C., Gyllensten, Katarina, Aleman, Anna, Ernberg, Ingemar, Åkerlund, Börje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185664/
https://www.ncbi.nlm.nih.gov/pubmed/21994658
http://dx.doi.org/10.3390/v2040867
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author Friis, Anna M. C.
Gyllensten, Katarina
Aleman, Anna
Ernberg, Ingemar
Åkerlund, Börje
author_facet Friis, Anna M. C.
Gyllensten, Katarina
Aleman, Anna
Ernberg, Ingemar
Åkerlund, Börje
author_sort Friis, Anna M. C.
collection PubMed
description We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
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spelling pubmed-31856642011-10-12 The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients Friis, Anna M. C. Gyllensten, Katarina Aleman, Anna Ernberg, Ingemar Åkerlund, Börje Viruses Article We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV. Molecular Diversity Preservation International (MDPI) 2010-03-29 /pmc/articles/PMC3185664/ /pubmed/21994658 http://dx.doi.org/10.3390/v2040867 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Friis, Anna M. C.
Gyllensten, Katarina
Aleman, Anna
Ernberg, Ingemar
Åkerlund, Börje
The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title_full The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title_fullStr The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title_full_unstemmed The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title_short The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients
title_sort effect of antiretroviral combination treatment on epstein-barr virus (ebv) genome load in hiv-infected patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185664/
https://www.ncbi.nlm.nih.gov/pubmed/21994658
http://dx.doi.org/10.3390/v2040867
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