Increasing the Efficacy of Oncolytic Adenovirus Vectors

Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tum...

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Autores principales: Toth, Karoly, Wold, William S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185754/
https://www.ncbi.nlm.nih.gov/pubmed/21994711
http://dx.doi.org/10.3390/v2091844
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author Toth, Karoly
Wold, William S. M.
author_facet Toth, Karoly
Wold, William S. M.
author_sort Toth, Karoly
collection PubMed
description Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tumor cells. Repeated cycles of vector replication and cell lysis can destroy the tumor. Numerous Ad vectors have been generated and tested, some of them reaching human clinical trials. In 2005, the first oncolytic Ad was approved for the treatment of head-and-neck cancer by the Chinese FDA. Oncolytic Ads have been proven to be safe, with no serious adverse effects reported even when high doses of the vector were injected intravenously. The vectors demonstrated modest anti-tumor effect when applied as a single agent; their efficacy improved when they were combined with another modality. The efficacy of oncolytic Ads can be improved using various approaches, including vector design, delivery techniques, and ancillary treatment, which will be discussed in this review.
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spelling pubmed-31857542011-10-12 Increasing the Efficacy of Oncolytic Adenovirus Vectors Toth, Karoly Wold, William S. M. Viruses Review Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tumor cells. Repeated cycles of vector replication and cell lysis can destroy the tumor. Numerous Ad vectors have been generated and tested, some of them reaching human clinical trials. In 2005, the first oncolytic Ad was approved for the treatment of head-and-neck cancer by the Chinese FDA. Oncolytic Ads have been proven to be safe, with no serious adverse effects reported even when high doses of the vector were injected intravenously. The vectors demonstrated modest anti-tumor effect when applied as a single agent; their efficacy improved when they were combined with another modality. The efficacy of oncolytic Ads can be improved using various approaches, including vector design, delivery techniques, and ancillary treatment, which will be discussed in this review. Molecular Diversity Preservation International (MDPI) 2010-08-27 /pmc/articles/PMC3185754/ /pubmed/21994711 http://dx.doi.org/10.3390/v2091844 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Toth, Karoly
Wold, William S. M.
Increasing the Efficacy of Oncolytic Adenovirus Vectors
title Increasing the Efficacy of Oncolytic Adenovirus Vectors
title_full Increasing the Efficacy of Oncolytic Adenovirus Vectors
title_fullStr Increasing the Efficacy of Oncolytic Adenovirus Vectors
title_full_unstemmed Increasing the Efficacy of Oncolytic Adenovirus Vectors
title_short Increasing the Efficacy of Oncolytic Adenovirus Vectors
title_sort increasing the efficacy of oncolytic adenovirus vectors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185754/
https://www.ncbi.nlm.nih.gov/pubmed/21994711
http://dx.doi.org/10.3390/v2091844
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