Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences

Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 an...

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Autores principales: Bertazzoni, Umberto, Turci, Marco, Avesani, Francesca, Di Gennaro, Gianfranco, Bidoia, Carlo, Romanelli, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185761/
https://www.ncbi.nlm.nih.gov/pubmed/21994745
http://dx.doi.org/10.3390/v3050541
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author Bertazzoni, Umberto
Turci, Marco
Avesani, Francesca
Di Gennaro, Gianfranco
Bidoia, Carlo
Romanelli, Maria Grazia
author_facet Bertazzoni, Umberto
Turci, Marco
Avesani, Francesca
Di Gennaro, Gianfranco
Bidoia, Carlo
Romanelli, Maria Grazia
author_sort Bertazzoni, Umberto
collection PubMed
description Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.
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spelling pubmed-31857612011-10-12 Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences Bertazzoni, Umberto Turci, Marco Avesani, Francesca Di Gennaro, Gianfranco Bidoia, Carlo Romanelli, Maria Grazia Viruses Review Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity. Molecular Diversity Preservation International (MDPI) 2011-05-09 /pmc/articles/PMC3185761/ /pubmed/21994745 http://dx.doi.org/10.3390/v3050541 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Bertazzoni, Umberto
Turci, Marco
Avesani, Francesca
Di Gennaro, Gianfranco
Bidoia, Carlo
Romanelli, Maria Grazia
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title_full Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title_fullStr Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title_full_unstemmed Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title_short Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
title_sort intracellular localization and cellular factors interaction of htlv-1 and htlv-2 tax proteins: similarities and functional differences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185761/
https://www.ncbi.nlm.nih.gov/pubmed/21994745
http://dx.doi.org/10.3390/v3050541
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