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Targeting HTLV-1 Activation of NFκB in Mouse Models and ATLL Patients

Of the millions of HTLV-1 infected carriers worldwide, 3–5% will develop an aggressive T-cell neoplasm that is highly refractory to conventional therapy. The virus carries the Tax oncogene which constitutively activates the NFκB pathway. This co-option of signaling through NFκB provides for the HTLV...

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Detalles Bibliográficos
Autores principales: Rauch, Daniel A., Ratner, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185776/
https://www.ncbi.nlm.nih.gov/pubmed/21994759
http://dx.doi.org/10.3390/v3060886

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