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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. N...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185784/ https://www.ncbi.nlm.nih.gov/pubmed/21994765 http://dx.doi.org/10.3390/v3070941 |
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author | Zaichick, Sofia V. Bohannon, Kevin P. Smith, Gregory A. |
author_facet | Zaichick, Sofia V. Bohannon, Kevin P. Smith, Gregory A. |
author_sort | Zaichick, Sofia V. |
collection | PubMed |
description | Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton. |
format | Online Article Text |
id | pubmed-3185784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31857842011-10-12 Alphaherpesviruses and the Cytoskeleton in Neuronal Infections Zaichick, Sofia V. Bohannon, Kevin P. Smith, Gregory A. Viruses Review Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton. Molecular Diversity Preservation International (MDPI) 2011-06-27 /pmc/articles/PMC3185784/ /pubmed/21994765 http://dx.doi.org/10.3390/v3070941 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zaichick, Sofia V. Bohannon, Kevin P. Smith, Gregory A. Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title | Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title_full | Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title_fullStr | Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title_full_unstemmed | Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title_short | Alphaherpesviruses and the Cytoskeleton in Neuronal Infections |
title_sort | alphaherpesviruses and the cytoskeleton in neuronal infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185784/ https://www.ncbi.nlm.nih.gov/pubmed/21994765 http://dx.doi.org/10.3390/v3070941 |
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