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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections

Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. N...

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Detalles Bibliográficos
Autores principales: Zaichick, Sofia V., Bohannon, Kevin P., Smith, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185784/
https://www.ncbi.nlm.nih.gov/pubmed/21994765
http://dx.doi.org/10.3390/v3070941
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author Zaichick, Sofia V.
Bohannon, Kevin P.
Smith, Gregory A.
author_facet Zaichick, Sofia V.
Bohannon, Kevin P.
Smith, Gregory A.
author_sort Zaichick, Sofia V.
collection PubMed
description Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
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spelling pubmed-31857842011-10-12 Alphaherpesviruses and the Cytoskeleton in Neuronal Infections Zaichick, Sofia V. Bohannon, Kevin P. Smith, Gregory A. Viruses Review Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton. Molecular Diversity Preservation International (MDPI) 2011-06-27 /pmc/articles/PMC3185784/ /pubmed/21994765 http://dx.doi.org/10.3390/v3070941 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zaichick, Sofia V.
Bohannon, Kevin P.
Smith, Gregory A.
Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title_full Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title_fullStr Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title_full_unstemmed Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title_short Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
title_sort alphaherpesviruses and the cytoskeleton in neuronal infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185784/
https://www.ncbi.nlm.nih.gov/pubmed/21994765
http://dx.doi.org/10.3390/v3070941
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