Viruses, Autophagy Genes, and Crohn’s Disease

The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in...

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Detalles Bibliográficos
Autores principales: Hubbard, Vanessa M., Cadwell, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185787/
https://www.ncbi.nlm.nih.gov/pubmed/21994779
http://dx.doi.org/10.3390/v3071281
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author Hubbard, Vanessa M.
Cadwell, Ken
author_facet Hubbard, Vanessa M.
Cadwell, Ken
author_sort Hubbard, Vanessa M.
collection PubMed
description The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
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spelling pubmed-31857872011-10-12 Viruses, Autophagy Genes, and Crohn’s Disease Hubbard, Vanessa M. Cadwell, Ken Viruses Review The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders. Molecular Diversity Preservation International (MDPI) 2011-07-21 /pmc/articles/PMC3185787/ /pubmed/21994779 http://dx.doi.org/10.3390/v3071281 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hubbard, Vanessa M.
Cadwell, Ken
Viruses, Autophagy Genes, and Crohn’s Disease
title Viruses, Autophagy Genes, and Crohn’s Disease
title_full Viruses, Autophagy Genes, and Crohn’s Disease
title_fullStr Viruses, Autophagy Genes, and Crohn’s Disease
title_full_unstemmed Viruses, Autophagy Genes, and Crohn’s Disease
title_short Viruses, Autophagy Genes, and Crohn’s Disease
title_sort viruses, autophagy genes, and crohn’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185787/
https://www.ncbi.nlm.nih.gov/pubmed/21994779
http://dx.doi.org/10.3390/v3071281
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