Correlates of Immunity to Filovirus Infection

Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus i...

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Detalles Bibliográficos
Autores principales: Bradfute, Steven B., Bavari, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185794/
https://www.ncbi.nlm.nih.gov/pubmed/21994766
http://dx.doi.org/10.3390/v3070982
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author Bradfute, Steven B.
Bavari, Sina
author_facet Bradfute, Steven B.
Bavari, Sina
author_sort Bradfute, Steven B.
collection PubMed
description Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment.
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spelling pubmed-31857942011-10-12 Correlates of Immunity to Filovirus Infection Bradfute, Steven B. Bavari, Sina Viruses Review Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment. Molecular Diversity Preservation International (MDPI) 2011-06-27 /pmc/articles/PMC3185794/ /pubmed/21994766 http://dx.doi.org/10.3390/v3070982 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Bradfute, Steven B.
Bavari, Sina
Correlates of Immunity to Filovirus Infection
title Correlates of Immunity to Filovirus Infection
title_full Correlates of Immunity to Filovirus Infection
title_fullStr Correlates of Immunity to Filovirus Infection
title_full_unstemmed Correlates of Immunity to Filovirus Infection
title_short Correlates of Immunity to Filovirus Infection
title_sort correlates of immunity to filovirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185794/
https://www.ncbi.nlm.nih.gov/pubmed/21994766
http://dx.doi.org/10.3390/v3070982
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