Cargando…

Randomised double-blind trial of megestrol acetate vs placebo in treatment-naive advanced hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS: From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chow, P K H, Machin, D, Chen, Y, Zhang, X, Win, K-M, Hoang, H-H, Nguyen, B-D, Jin, M-Y, Lobo, R, Findlay, M, Lim, C-H, Tan, S-B, Gandhi, M, Soo, K-C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185948/ https://www.ncbi.nlm.nih.gov/pubmed/21863030 http://dx.doi.org/10.1038/bjc.2011.333

Ejemplares similares

Megestrol acetate in cachexia and anorexia
por: Yeh, Shing-shing, et al.
Publicado: (2006)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss
por: McMillan, D C, et al.
Publicado: (1999)

A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
por: McMillan, D. C., et al.
Publicado: (1997)

A randomised, double blind, placebo-controlled trial of megestrol acetate or dexamethasone in treating symptomatic anorexia in people with advanced cancer
por: Currow, David C., et al.
Publicado: (2021)

Megestrol Acetate Induced Paradoxical Embolism in a Sickle Cell Disease Patient
por: Dominguez, Lisette, et al.
Publicado: (2019)

Megestrol Acetate-Induced Symptomatic Hypogonadism in a Male Patient
por: Munshi, Lubna Bashir, et al.
Publicado: (2018)

Megestrol acetate for cachexia–anorexia syndrome. A systematic review
por: Ruiz‐García, Vicente, et al.
Publicado: (2018)

New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate
por: Lachowicz, Malwina, et al.
Publicado: (2016)

Exogenous Cushing’s Syndrome, Hypogonadism and Diabetes Secondary to Megestrol Acetate
por: Baby, Merilyn, et al.
Publicado: (2021)

Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer
por: Wen, Wei, et al.
Publicado: (2017)

Influence of megestrol acetate on nutrition, inflammation and quality of life in dialysis patients
por: Gołębiewska, Justyna E., et al.
Publicado: (2011)

Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia
por: Shan, Weiwei, et al.
Publicado: (2014)

Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate
por: Islam, Mohammad Saiful, et al.
Publicado: (2021)

Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension
por: Deschamps, Benoit, et al.
Publicado: (2009)

SUN-031 Megestrol Acetate for Bodybuilding Resulting in Abrupt Hypothalamic-Pituitary Dysfunction
por: Lessard, Kimberly Kochersperger, et al.
Publicado: (2020)

Characterizing the Drug-Release Enhancement Effect of Surfactants on Megestrol-Acetate-Loaded Granules
por: Katona, Gábor, et al.
Publicado: (2022)

Megestrol acetate versus metronomic cyclophosphamide in patients having exhausted all effective therapies under standard care
por: Penel, N, et al.
Publicado: (2010)

Precipitation Reaction of SDS and Potassium Salts in Flocculation of a Micronized Megestrol Acetate Suspension
por: Hejazi, Seyed Mahdi, et al.
Publicado: (2013)

Megestrol treatment in patients with hepatocellular carcinoma
por: Farinati, F, et al.
Publicado: (2001)

Megestrol acetate improves cardiac function in a model of cancer cachexia‐induced cardiomyopathy by autophagic modulation
por: Musolino, Vincenzo, et al.
Publicado: (2016)

Safety of Megestrol Acetate in Palliating Anorexia-Cachexia Syndrome in Patients with Castration-Resistant Prostate Cancer
por: Hong, Sungwoo, et al.
Publicado: (2013)

Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma.
por: Wood, L., et al.
Publicado: (1998)

Long-term efficacy of megestrol acetate and tamoxifen in a recurrent adult granulosa cell tumor of the ovary
por: Moon, Ashley S., et al.
Publicado: (2021)

A Systematic Review and Meta-Analysis of the Clinical Use of Megestrol Acetate for Cancer-Related Anorexia/Cachexia
por: Lim, Yu Liang, et al.
Publicado: (2022)

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state
por: Jang, Kyungho, et al.
Publicado: (2014)

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process
por: Ha, Eun-Sol, et al.
Publicado: (2015)

Megestrol Acetate for Heavily Pretreated Metastatic Castration-Resistant Prostate Cancer: An Old Answer for a New Problem
por: La Vecchia, Maria, et al.
Publicado: (2022)

Hormonal therapy with megestrol in inoperable hepatocellular carcinoma characterized by variant oestrogen receptors
por: Villa, E, et al.
Publicado: (2001)

SAT319 Megestrol-induced Adrenal Insufficiency
por: Alcorn, Chris, et al.
Publicado: (2023)

Prospective randomised trial of two dose levels of megestrol acetate in the management of anorexia-cachexia syndrome in patients with metastatic cancer.
por: Gebbia, V., et al.
Publicado: (1996)

Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice.
por: Beck, S. A., et al.
Publicado: (1990)

A double blind placebo controlled trial of medroxyprogesterone acetate (MPA) in cancer cachexia.
por: Downer, S., et al.
Publicado: (1993)

Effect of Megestrol Acetate Combined With Oral Nutrition Supplement in Malnourished Lung Cancer Patients: A Single-Center Prospective Cohort Study
por: Duan, Baojun, et al.
Publicado: (2021)

P1030: MANIFEST-2, A GLOBAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROL STUDY OF PELABRESIB (CPI-0610) AND RUXOLITINIB VS PLACEBO AND RUXOLITINIB IN JAK INHIBITOR-NAÏVE MYELOFIBROSIS PATIENTS
por: Harrison, C., et al.
Publicado: (2022)

Norethindrone substituted for megestrol in the treatment of metastatic endometrial carcinoma: Three cases
por: Read, William L., et al.
Publicado: (2017)

Hysteroscopic Curettage Followed by Megestrol Acetate Plus Metformin as a Fertility-Sparing Treatment for Women with Atypical Endometrial Hyperplasia or Well-Differentiated Endometrioid Endometrial Carcinoma
por: Jing, Chu-Yu, et al.
Publicado: (2022)

Feasibility and Activity of Megestrol Acetate in Addition to Etoposide, Doxorubicin, Cisplatin, and Mitotane as First-Line Therapy in Patients with Metastatic/Unresectable Adrenocortical Carcinoma with Low Performance Status
por: Turla, Antonella, et al.
Publicado: (2023)

Efficacy and safety of megestrol in the management of hepatocellular carcinoma: a systematic review of the literature
por: Rawla, Prashanth, et al.
Publicado: (2018)

Adjuvant durvalumab for esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a placebo-controlled, randomized, double-blind, phase II study
por: Park, S., et al.
Publicado: (2022)

Mirtazapine versus Megestrol in the Treatment of Anorexia–Cachexia Syndrome in Patients with Advanced Cancer: A Randomized, Double-Blind, Controlled Phase II Clinical Trial
por: Almeida, Olga Laura Sena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qgg6nipigqha4ag07pv9noun1u