Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)

Perilipin (PLIN1) is a constitutive adipocyte lipid droplet coat protein. N-terminal amphipathic helices and central hydrophobic stretches are thought to anchor it on the lipid droplet, where it appears to function as a scaffold protein regulating lipase activity. We recently identified two differen...

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Detalles Bibliográficos
Autores principales: Gandotra, Sheetal, Lim, Koini, Girousse, Amandine, Saudek, Vladimir, O'Rahilly, Stephen, Savage, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186430/
https://www.ncbi.nlm.nih.gov/pubmed/21757733
http://dx.doi.org/10.1074/jbc.M111.278853

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