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Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 resident...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186755/ https://www.ncbi.nlm.nih.gov/pubmed/21991401 http://dx.doi.org/10.1371/journal.pntd.0001339 |
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author | Kim, Jae-Hwan Choi, Min-Ho Bae, Young Mee Oh, Jin-Kyoung Lim, Min Kyung Hong, Sung-Tae |
author_facet | Kim, Jae-Hwan Choi, Min-Ho Bae, Young Mee Oh, Jin-Kyoung Lim, Min Kyung Hong, Sung-Tae |
author_sort | Kim, Jae-Hwan |
collection | PubMed |
description | BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006–2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1–1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000. |
format | Online Article Text |
id | pubmed-3186755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31867552011-10-11 Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis Kim, Jae-Hwan Choi, Min-Ho Bae, Young Mee Oh, Jin-Kyoung Lim, Min Kyung Hong, Sung-Tae PLoS Negl Trop Dis Research Article BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006–2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1–1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000. Public Library of Science 2011-10-04 /pmc/articles/PMC3186755/ /pubmed/21991401 http://dx.doi.org/10.1371/journal.pntd.0001339 Text en Kim et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Jae-Hwan Choi, Min-Ho Bae, Young Mee Oh, Jin-Kyoung Lim, Min Kyung Hong, Sung-Tae Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title | Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title_full | Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title_fullStr | Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title_full_unstemmed | Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title_short | Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis |
title_sort | correlation between discharged worms and fecal egg counts in human clonorchiasis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186755/ https://www.ncbi.nlm.nih.gov/pubmed/21991401 http://dx.doi.org/10.1371/journal.pntd.0001339 |
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