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Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 resident...

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Autores principales: Kim, Jae-Hwan, Choi, Min-Ho, Bae, Young Mee, Oh, Jin-Kyoung, Lim, Min Kyung, Hong, Sung-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186755/
https://www.ncbi.nlm.nih.gov/pubmed/21991401
http://dx.doi.org/10.1371/journal.pntd.0001339
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author Kim, Jae-Hwan
Choi, Min-Ho
Bae, Young Mee
Oh, Jin-Kyoung
Lim, Min Kyung
Hong, Sung-Tae
author_facet Kim, Jae-Hwan
Choi, Min-Ho
Bae, Young Mee
Oh, Jin-Kyoung
Lim, Min Kyung
Hong, Sung-Tae
author_sort Kim, Jae-Hwan
collection PubMed
description BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006–2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1–1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000.
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spelling pubmed-31867552011-10-11 Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis Kim, Jae-Hwan Choi, Min-Ho Bae, Young Mee Oh, Jin-Kyoung Lim, Min Kyung Hong, Sung-Tae PLoS Negl Trop Dis Research Article BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006–2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1–1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000. Public Library of Science 2011-10-04 /pmc/articles/PMC3186755/ /pubmed/21991401 http://dx.doi.org/10.1371/journal.pntd.0001339 Text en Kim et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Jae-Hwan
Choi, Min-Ho
Bae, Young Mee
Oh, Jin-Kyoung
Lim, Min Kyung
Hong, Sung-Tae
Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title_full Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title_fullStr Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title_full_unstemmed Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title_short Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
title_sort correlation between discharged worms and fecal egg counts in human clonorchiasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186755/
https://www.ncbi.nlm.nih.gov/pubmed/21991401
http://dx.doi.org/10.1371/journal.pntd.0001339
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