Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

Sclerostin is a product of mature osteocytes embedded in mineralised bone and is a negative regulator of bone mass and osteoblast differentiation. While evidence suggests that sclerostin has an anti-anabolic role, the possibility also exists that sclerostin has catabolic activity. To test this we tr...

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Detalles Bibliográficos
Autores principales: Wijenayaka, Asiri R., Kogawa, Masakazu, Lim, Hui Peng, Bonewald, Lynda F., Findlay, David M., Atkins, Gerald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186800/
https://www.ncbi.nlm.nih.gov/pubmed/21991382
http://dx.doi.org/10.1371/journal.pone.0025900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186800/
https://www.ncbi.nlm.nih.gov/pubmed/21991382
http://dx.doi.org/10.1371/journal.pone.0025900

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