Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase

Anti-apoptotic Bcl2 family proteins such as Bcl-x(L) protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal function. We find in hippocampal neurons that Bcl-x(L) enhances the efficiency of energy metabolism. Our evidence suggests that Bcl-x(L) interacts...

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Detalles Bibliográficos
Autores principales: Alavian, Kambiz N., Li, Hongmei, Collis, Leon, Bonanni, Laura, Zeng, Lu, Sacchetti, Silvio, Lazrove, Emma, Nabili, Panah, Flaherty, Benjamin, Graham, Morven, Chen, Yingbei, Messerli, Shanta, Mariggio, Maria A., Rahner, Christoph, McNay, Ewan, Shore, Gordon, Smith, Peter J. S., Hardwick, J. Marie, Jonas, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186867/
https://www.ncbi.nlm.nih.gov/pubmed/21926988
http://dx.doi.org/10.1038/ncb2330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186867/
https://www.ncbi.nlm.nih.gov/pubmed/21926988
http://dx.doi.org/10.1038/ncb2330

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