Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm

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Granzyme B (GZMB) is a proapoptotic serine protease that is released by cytotoxic lymphocytes. However, GZMB can also be produced by other cell types and is capable of cleaving extracellular matrix (ECM) proteins. GZMB contributes to abdominal aortic aneurysm (AAA) through an extracellular, perforin...

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Detalles Bibliográficos
Autores principales: Ang, L S, Boivin, W A, Williams, S J, Zhao, H, Abraham, T, Carmine-Simmen, K, McManus, B M, Bleackley, R C, Granville, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186906/
https://www.ncbi.nlm.nih.gov/pubmed/21900960
http://dx.doi.org/10.1038/cddis.2011.88
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