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Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women
Background: Murine studies suggest a beneficial effect of systemic adiponectin on asthma. Our objective was to determine the association between serum adiponectin concentrations and asthma control/severity outcomes in men and women separately. Methods: Cross-sectional and longitudinal analyses of da...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186942/ https://www.ncbi.nlm.nih.gov/pubmed/22007173 http://dx.doi.org/10.3389/fphar.2011.00055 |
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author | Sood, Akshay Dominic, Elizabeth Qualls, Clifford Steffes, Michael W. Thyagarajan, Bharat Smith, Lewis J. Lewis, Cora E. Jacobs, David R. |
author_facet | Sood, Akshay Dominic, Elizabeth Qualls, Clifford Steffes, Michael W. Thyagarajan, Bharat Smith, Lewis J. Lewis, Cora E. Jacobs, David R. |
author_sort | Sood, Akshay |
collection | PubMed |
description | Background: Murine studies suggest a beneficial effect of systemic adiponectin on asthma. Our objective was to determine the association between serum adiponectin concentrations and asthma control/severity outcomes in men and women separately. Methods: Cross-sectional and longitudinal analyses of data from years 10, 15, and 20 examinations of the prospective coronary artery risk development in young adults study in the United States were performed. Asthma was defined by self-reported provider diagnosis at or prior to year 15 examination. Outcomes included presence of active disease, number of respiratory symptoms, and number of asthma medications; as well as longitudinal decline in absolute FEV(1). Year 15 serum adiponectin concentration was the predictor variable. Results: In a multivariable analysis of 411 eligible subjects, after adjusting for body mass index and covariates, higher serum adiponectin concentrations were associated with more frequent active disease (including more frequent use of any asthma medication), and greater number of respiratory symptoms and asthma medications among men but not among women with asthma (p for interactions between sex and adiponectin for all analyses < 0.05). Conclusions: Higher serum adiponectin concentrations may be independently associated with adverse clinical outcomes of asthma in men but not in women. If biological effect is confirmed in future studies, modification of systemic adiponectin concentrations may open up newer ways to treat asthma in men. |
format | Online Article Text |
id | pubmed-3186942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31869422011-10-17 Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women Sood, Akshay Dominic, Elizabeth Qualls, Clifford Steffes, Michael W. Thyagarajan, Bharat Smith, Lewis J. Lewis, Cora E. Jacobs, David R. Front Pharmacol Pharmacology Background: Murine studies suggest a beneficial effect of systemic adiponectin on asthma. Our objective was to determine the association between serum adiponectin concentrations and asthma control/severity outcomes in men and women separately. Methods: Cross-sectional and longitudinal analyses of data from years 10, 15, and 20 examinations of the prospective coronary artery risk development in young adults study in the United States were performed. Asthma was defined by self-reported provider diagnosis at or prior to year 15 examination. Outcomes included presence of active disease, number of respiratory symptoms, and number of asthma medications; as well as longitudinal decline in absolute FEV(1). Year 15 serum adiponectin concentration was the predictor variable. Results: In a multivariable analysis of 411 eligible subjects, after adjusting for body mass index and covariates, higher serum adiponectin concentrations were associated with more frequent active disease (including more frequent use of any asthma medication), and greater number of respiratory symptoms and asthma medications among men but not among women with asthma (p for interactions between sex and adiponectin for all analyses < 0.05). Conclusions: Higher serum adiponectin concentrations may be independently associated with adverse clinical outcomes of asthma in men but not in women. If biological effect is confirmed in future studies, modification of systemic adiponectin concentrations may open up newer ways to treat asthma in men. Frontiers Research Foundation 2011-10-05 /pmc/articles/PMC3186942/ /pubmed/22007173 http://dx.doi.org/10.3389/fphar.2011.00055 Text en Copyright © 2011 Sood, Dominic, Qualls, Steffes, Thyagarajan, Smith, Lewis and Jacobs Jr. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Pharmacology Sood, Akshay Dominic, Elizabeth Qualls, Clifford Steffes, Michael W. Thyagarajan, Bharat Smith, Lewis J. Lewis, Cora E. Jacobs, David R. Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title | Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title_full | Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title_fullStr | Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title_full_unstemmed | Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title_short | Serum Adiponectin is Associated with Adverse Outcomes of Asthma in Men but Not in Women |
title_sort | serum adiponectin is associated with adverse outcomes of asthma in men but not in women |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186942/ https://www.ncbi.nlm.nih.gov/pubmed/22007173 http://dx.doi.org/10.3389/fphar.2011.00055 |
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