Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function

Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Stapleford, Kenneth A., Miller, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187604/
https://www.ncbi.nlm.nih.gov/pubmed/21994671
http://dx.doi.org/10.3390/v2051055
_version_ 1782213321847472128
author Stapleford, Kenneth A.
Miller, David J.
author_facet Stapleford, Kenneth A.
Miller, David J.
author_sort Stapleford, Kenneth A.
collection PubMed
description Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
format Online
Article
Text
id pubmed-3187604
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-31876042011-10-12 Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function Stapleford, Kenneth A. Miller, David J. Viruses Review Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process. Molecular Diversity Preservation International (MDPI) 2010-04-29 /pmc/articles/PMC3187604/ /pubmed/21994671 http://dx.doi.org/10.3390/v2051055 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Stapleford, Kenneth A.
Miller, David J.
Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title_full Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title_fullStr Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title_full_unstemmed Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title_short Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
title_sort role of cellular lipids in positive-sense rna virus replication complex assembly and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187604/
https://www.ncbi.nlm.nih.gov/pubmed/21994671
http://dx.doi.org/10.3390/v2051055
work_keys_str_mv AT staplefordkennetha roleofcellularlipidsinpositivesensernavirusreplicationcomplexassemblyandfunction
AT millerdavidj roleofcellularlipidsinpositivesensernavirusreplicationcomplexassemblyandfunction

Ejemplares similares